MONASTROL
MONASTROL ??? ???
?? ??:
329689-23-8
???:
MONASTROL
???(??):
CS-763;MONASTROL;(±)-Monastro;Monastrol, >=98%;MONASTROL (Free base);Monastrol, cell permeable mitosis inhibitor;Ethyl 4-(3-hydroxyphenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate;6-Methyl-4-(3-hydroxyphenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester;5-PyriMidinecarboxylic acid, 1,2,3,4-tetrahydro-4-(3-hydroxyphenyl)-6-Methyl-2-thioxo-, ethyl ester
CBNumber:
CB92130960
???:
C14H16N2O3S
??? ??:
292.35
MOL ??:
329689-23-8.mol
MONASTROL ??
???
190-193℃ (ethanol )
?? ?
441.3±55.0 °C(Predicted)
??
1.34±0.1 g/cm3 (20 ºC 760 Torr)
RTECS ??
UV6262400
?? ??
under inert gas (nitrogen or Argon) at 2-8°C
???
DMSO(?? ???), ???????(?? ???), ???(?? ???, ??)
??? ??
?? ?? ??? ??.
?? ?? (pKa)
9.63±0.10(Predicted)
??
???? ?????
??
Light Sensitive
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
??·?? ??:
??
??·?? ??
?? ??
??
?? ?
?? ??
P- ??
H227 ??? ??
??? ??
?? 4
??
P210, P280, P370+P378, P403+P235,P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
??????:
P210 ?·???·??·????? ????? - ?? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P332+P313 ?? ??? ??? ???? ??· ??? ????.
P337+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P370+P378 ?? ? ?? ?? ?? (Section 5. ??, ??? ????? ??? ???)?(?) ?????.
P403+P235 ??? ? ?? ?? ???? ???? ?????.
P501 ...? ??? / ??? ?? ???.
MONASTROL C??? ??, ??, ??
??
Monastrol is a small molecule that inhibits mitotic kinesin Eg5 and arrests cells in mitosis with monopolar spindles (1, 2).Monastrol is an anticancer agent against MCF-7 tumor cells (3).
??
ChEBI: A member of the class of thioureas that is 3,4-dihydropyrimidine-2(1)-thione substituted by a 3-hydroxyphenyl group at position 4, a methyl group at position 6 and a ethoxycarbonyl group at position 5.
MONASTROL ?? ?? ? ???
???
?? ??
MONASTROL ?? ??
???( 121)?? ??
China 108
India 1
United States 12
Global 121
