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Trimethyl orthobenzoate

Trimethyl orthobenzoate ??? ???
?? ??:
707-07-3
???:
Trimethyl orthobenzoate
???(??):
(Trimethoxymethyl)benzene;Methyl orthobenzoate;Benzene, (trimethoxymethyl)-;SKL283;NSC-67391;Orthobenzoate;trimethyl benzoate;TRIMETHYL-O-BENZOATE;Intedanib Impurity 6;Sunitinib Impurity 71
CBNumber:
CB9160297
???:
C10H14O3
??? ??:
182.22
MOL ??:
707-07-3.mol
MSDS ??:
SDS

Trimethyl orthobenzoate ??

?? ?
87-88 °C/7 mmHg (lit.)
??
1.061 g/mL at 25 °C (lit.)
???
n20/D 1.489(lit.)
???
180 °F
?? ??
Inert atmosphere,Room Temperature
???
?? ??? ?????.
??? ??
??
??
???
??
Moisture Sensitive
BRN
777623
???
???
InChIKey
IECKAVQTURBPON-UHFFFAOYSA-N
CAS ??????
707-07-3(CAS DataBase Reference)
NIST
Benzene, (trimethoxymethyl)-(707-07-3)
EPA
Benzene, (trimethoxymethyl)- (707-07-3)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36/37/39-37/39
WGK ?? 3
TSCA Yes
HS ?? 29163100
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P302+P352 ??? ??? ??? ?? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
2
2 1

Trimethyl orthobenzoate C??? ??, ??, ??

??? ??

clear colorless liquid

??

Trimethyl Orthobenzoate is a reagent used in the synthesis of quinazolines. Also used in the prepaaration of nintedanib (N478290), used in the treatment of idiopathic pulmonary fibrosis. Also inhibits the process blood vessel formation which may be used to assist in cancer therapy.

?? ??

Trimethyl orthobenzoate reacts with P-dimethylaminophosphonic acid bis(1-methylhydrazide) to yield 1,2,5,6-tetrahydro-1,5-dimethyl-6-(N,N-dimethylamino)-6-phenyl-1,2,4,5,6-tetrazaphosphorine-6-oxide.

Trimethyl orthobenzoate ?? ?? ? ???

???

?? ??


Trimethyl orthobenzoate ?? ??

???( 296)?? ??
??? ?? ??? ?? ?? ? ??
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Trimethyl orthobenzoate ?? ??:

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