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SCH 58261

SCH 58261 ??? ???
?? ??:
160098-96-4
???:
SCH 58261
???(??):
CS-2187;SCH-58261;SCH 58261;SCH 58261, 10 mM in DMSO;SCH-58261, A2A antagonist;Butanoicacid,4-bromo-5-oxo-,ethylester;Inhibitor,inhibit,SCH-58261,Adenosine Receptor,SCH 58261,P1 receptor;2-(Furan-2-yl)-7-phenethyl-7H-pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyriMidin-5-aMine;7H-Pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidin-5-amine, 2-(2-furanyl)-7-(2-phenylethyl)-;4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexazatricyclo[7.3.0.02,6]dodeca-1(9),2,4,7,11-pentaen-7-amine;4-(furan-2-yl)-10-(2-phenylethyl)-3,5,6,8,10,11-hexaazatricyclo[7.3.0.0^{2,6}]dodeca-1(9),2,4,7,11-pentaen-7-amine
CBNumber:
CB8497477
???:
C18H15N7O
??? ??:
345.36
MOL ??:
160098-96-4.mol
MSDS ??:
SDS

SCH 58261 ??

???
223 °C
??
1.54±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,2-8°C
???
DMSO: >10mg/mL, ???
?? ?? (pKa)
2.78±0.30(Predicted)
??? ??
??
??? ??
??? ??
??
???
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
HS ?? 2934.99.3000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
NFPA 704
0
2 0

SCH 58261 C??? ??, ??, ??

??

SCH 58261 is a potent and selective A2A adenosine receptor antagonist.

???? ??

Potent and selective A 2A adenosine receptor competitive antagonist (K i = 1.3 nM). Displays 323-, 53- and 100-fold selectivity over A 1 , A 2B and A 3 receptors, respectively.

Biochem/physiol Actions

SCH 58261 reduces the levels of TNF-α, Fas-L, Bax expression and activation of JNK-MAPK pathway. It has neuroprotective effects as it reduces demyelination of the neurons. SCH 58261 increases the concentration of secretion of dopamine and elicits locomotor sensitization, an attractive option in the possible treatment of Parkinson′s disease.

SCH 58261 ?? ?? ? ???

???

5-Amino-1-phenethyl-1H-pyrazole-4-carbonitrile 2-??????? ?????

?? ??

SCH 58261 ?? ??

???( 118)?? ??
??? ?? ??? ?? ?? ? ??
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SCH 58261 ?? ??:

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