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PROTOPINE HYDROCHLORIDE

PROTOPINE HYDROCHLORIDE ??? ???
?? ??:
6164-47-2
???:
PROTOPINE HYDROCHLORIDE
???(??):
Nsc11440;FUMARINE;MACLEYINE;PROTOPINE HCL;PROTOHYPERICIN(RG);Argemonine (protopine;FUMARINE HYDROCHLORIDE;PROTOPINE HYDROCHLORIDE;13a-secoberbin-13a-one,7-methyl-2,3:9,10-bis(methylenedioxy)-hydrochloride;7,13A-Secoberbin-13A-one, 7-methyl-2,3:9,10-bis(methylenedioxy)-, hydrochloride
CBNumber:
CB8276092
???:
C20H20ClNO5
??? ??:
389.83
MOL ??:
6164-47-2.mol

PROTOPINE HYDROCHLORIDE ??

?? ??
2-8°C
???
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
??? ??
??
??? ??
??? ??
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? T
?? ???? ?? 25
????? 36/37/39-45
????(UN No.) 1544
WGK ?? 3
RTECS ?? UL2000000
?? ?? 6.1(b)
???? III
?? ?? ??? 6164-47-2(Hazardous Substances Data)
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H301 ??? ??? ?? ?? ?? - ?? ?? 3 ?? GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P310 ???? ?? ????(??)? ??? ????.
P321 (…) ??? ???.
P330 ?? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

PROTOPINE HYDROCHLORIDE C??? ??, ??, ??

??

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities. It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM. Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine and is a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes. Protopine inhibits the growth of H. pylori with an MIC50 value of 100 μg/ml. It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest. Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole .

??

Protopine hydrochloride may be used in the calibration curve preparation for the quantification of alkaloids from Fumaria capreolata using liquid chromatography coupled to diode array detection and electrospray ionization tandem mass spectrometry (LC-DAD-MS) and tandem mass spectrometry(MS/MS). It may also be used as an alkaloid in cytotoxicity and permeability studies carcinogenic cell lines.

?? ??

Protopine is a celandine alkaloid and a bioactive compound associated with the plant families including fumariaceae, berberidaceae?and papaveraceae. It is metabolized by demethylenation in the presence of the cytochrome enzymes cytochrome P450 family 2 subfamily d polypeptide 1 (CYP2D1) and cytochrome P450 family 2 subfamily c polypeptide 11 (CYP2C11).

PROTOPINE HYDROCHLORIDE ?? ?? ? ???

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PROTOPINE HYDROCHLORIDE ?? ??

???( 44)?? ??
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