ChemicalBook >?? ???? >N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-????????????
N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-????????????
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N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-???????????? ??
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- 2-8°C
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- H2O: ???2mg/mL, ??(???)
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- H2O: 2mg/mL, clear (warmed)
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WGK ?? | 3 |
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N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-???????????? C??? ??, ??, ??
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M8-B is an antagonist of transient receptor potential melastatin 8 (TRPM8) that blocks activation by cold, icilin , or menthol in vitro (IC50s = 7.8, 26.9, and 64.3 nM, respectively). It displays no effect at other TRP channels. M8-B decreases deep body temperature in wild-type mice and rats but has no effect on body temperature in TRPM8 KO mice.??
M8 B Hydrochloride is a channel blocker of cold receptor TRPM8.N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-???????????? ?? ?? ? ???
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N-(2-?????)-N-[[3-???-4-(?????)??]??]-2-???????????? ?? ??
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