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JAK2 Inhibitor IV

JAK2 Inhibitor IV ??? ???
?? ??:
1110502-30-1
???:
JAK2 Inhibitor IV
???(??):
JAK2 inhibitor 13;JAK2 Inhibitor IV;JAK2 inhibitor 13 - Sulfonamide 13;4-(3-amino-1H-indazol-5-yl)-N-(tert-butyl)benzenesulfonamide;4-(3-Amino-1H-indazol-5-yl)-N-(2-methyl-2-propanyl)benzenesulfonamide;Benzenesulfonamide, 4-(3-amino-1H-indazol-5-yl)-N-(1,1-dimethylethyl)-
CBNumber:
CB82535883
???:
C17H20N4O2S
??? ??:
344.43
MOL ??:
1110502-30-1.mol
MSDS ??:
SDS

JAK2 Inhibitor IV ??

?? ?
594.4±60.0 °C(Predicted)
??
1.310±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
ethanol: 3mg/mL
DMSO: 5mg/mL
??? ??
??
??? ??
??? ??
?? ?? (pKa)
11.90±0.50(Predicted)
??
pale yellow
??
Light Sensitive
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P405 ???? ?????.

JAK2 Inhibitor IV C??? ??, ??, ??

??

An aminoindazole compound that potently inhibits the activity of both the wild-type JAK2 and the active V617F mutant

JAK2 Inhibitor IV ?? ?? ? ???

???

?? ??

JAK2 Inhibitor IV ?? ??

???( 11)?? ??
??? ?? ??? ?? ?? ? ??
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