ChemicalBook >?? ???? >Tetraethylene glycol p-toluenesulfonate
Tetraethylene glycol p-toluenesulfonate
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Tetraethylene glycol p-toluenesulfonate ??
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- 492.5±40.0 °C(Predicted)
- ??
- 1.202 g/mL at 25 °C
- ???
- n20/D1.507
- ???
- >110℃
- ?? ??
- 2-8°C
- ???
- Soluble in Water, DMSO, DCM, DMF
- ??? ??
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- ?? ?? (pKa)
- 14.36±0.10(Predicted)
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- ?? ? ???? ?? (GHS)
| ??? ?? | T,Xi | ||
|---|---|---|---|
| ?? ???? ?? | 25-34-36 | ||
| ????? | 26-36/37/39-45 | ||
| ????(UN No.) | UN 2927 8(6.1) / PGII | ||
| WGK ?? | 3 |
| ????(GHS): |
 
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| ?? ?: | Danger | |||||||||||||||||||||
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Tetraethylene glycol p-toluenesulfonate C??? ??, ??, ??
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Tetraethylene glycol monotosylate is a cleavable and acylhydrazone-based ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Tetraethylene glycol monotosylate also can be used as a PROTAC linker that can be used in the synthesis of PROTACs.?? ??
Synthesis of tetraethylene glycol tosylate. To a solution of tetraethylene glycol (2.22 g, 11.4 mmol, 3.8 equiv) in THF at 0 °C was added 2.5 M NaOH (2 mL, 5.0 mmol, 1.7 equiv) and stirred for 30 min. Tosyl chloride (565.3 mg, 3.0 mmol, 1 equiv) was added in small portions and the mixture stirred for 5 h. The solvent was removed under reduced pressure, and the residue was taken up in CH2Cl2 (15 mL) and washed with water (3 × 10 mL). The aqueous wash was further extracted with CH2Cl2 (3 × 10 mL) and the combined organic fractions were washed with brine and dried over anhydrous Na2SO4. The dried solution was filtered and the filtrate was concentrated under reduced pressure to give 900.8 mg of a pale yellow oil (87%). The product was sufficiently pure to be used without further purification.
Tetraethylene glycol p-toluenesulfonate ?? ?? ? ???
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Tetraethylene glycol p-toluenesulfonate ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
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| TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38671 | 58 |
Tetraethylene glycol p-toluenesulfonate ?? ??:
Hydroxy-PEG4-C2-PFP ester
Hydroxy-PEG7-C2-PFP ester
1-METHANESULFONYL-11-HYDROXY-3,6,9-TRIOXAUNDECANE
PEG6-Tos
TETRAETHYLENE GLYCOL DI-P-TOSYLATE
m-PEG5-Tos
2-(2-(2-Methoxyethoxy)ethoxy)ethyl 4-Methylbenzenesulfonate
TRI(ETHYLENE GLYCOL) MONOMETHYL ETHER TOSYLATE
BroMoMethyl -phosphonic acid diethyl ester
Ethanol, 2-[2-(2-hydroxyethoxy)ethoxy]-, 1-(4-Methylbenzenesulfonate)
Hydroxy-PEG5-C2-PFP ester
PEG13-Tos
PEG7-Tos
Hydroxy-PEG3-PFP ester
2-(4-Methylphenyl)sulfonyloxyethanol
Tos-PEG10-OH
Hydroxy-PEG1-C2-PFP ester
PEG8-Tos