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Cefditoren pivoxil

Cefditoren pivoxil ??? ???
?? ??:
117467-28-4
???:
Cefditoren pivoxil
???(??):
CEFDITOREN;Spectracef;CEFDITORIN PIVOXIL;Meiac;MEIACT;ME-1207;toubaotuolunzhi;toubaotuolkunzhi;ceditoren pivoxil;Cefditoren Pivoxi
CBNumber:
CB7377697
???:
C25H28N6O7S3
??? ??:
620.72
MOL ??:
117467-28-4.mol
MSDS ??:
SDS

Cefditoren pivoxil ??

???
207-209°C
??
D20 -48.5° (c = 0.5 in methanol)
??
1.55±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
???
DMSO(?? ???), ???(?? ???), ???(?? ???, ??)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
8.08±0.60(Predicted)
??
????? ?? ???
Merck
14,1921
InChIKey
AFZFFLVORLEPPO-UVYJNCLZSA-N
SMILES
N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\OC)=O)C1=O)SCC(/C=C\C1SC=NC=1C)=C2C(OCOC(=O)C(C)(C)C)=O
CAS ??????
117467-28-4(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
RTECS ?? XI0367800
HS ?? 2941.90.3000
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P272 ??? ??? ??? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P285 ??? ? ?? ?? ???? ??? ???? ?????
P302+P352 ??? ??? ??? ?? ????.
P304+P341 ???? ??,??? ??? ?? ??? ??? ??? ?? ??? ??? ???? ?? ??? ??? ??? ?
P321 (…) ??? ???.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P342+P311 ??? ??? ???? ????(??)? ??? ????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.

Cefditoren pivoxil C??? ??, ??, ??

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Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.

??? ??

Off-White Powder

??

Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.

??

ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.

Antimicrobial activity

It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.

Pharmacokinetics

Oral absorption: c. 70%
Cmax 200 mg oral: c. 1.8 mg/L after 1.5–3 h
Plasma half-life: 0.8–1.3 h
Volume of distribution: 9.3 L
Plasma protein binding: 88%
After oral administration the pivaloyl ester is rapidly cleaved by esterases in the gut wall. Ingestion with food improves the bioavailability. Plasma concentrations are raised in elderly patients. There is no accumulation on repeated dosing.
It is excreted unchanged in the urine with a half-life of around 1.5 h, achieving a concentration of 150–200 mg/L within 4 h. Dosage adjustment is recommended in patients with deteriorating renal function.

Clinical Use

It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.

???

In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.

Cefditoren pivoxil ?? ?? ? ???

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Cefditoren pivoxil ?? ??

???( 369)?? ??
??? ?? ??? ?? ?? ? ??
Watson Biotechnology Co.,Ltd
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CONIER CHEM AND PHARMA LIMITED
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Hebei Runbin Biotechnology Co. LTD
13180553332
2179877681@qq.com CHINA 990 58
TargetMol Chemicals Inc.
+17819995354
marketing@targetmol.com United States 32301 58

Cefditoren pivoxil ?? ??:

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