Cefditoren pivoxil ??

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Cefditoren pivoxil is an orally active third generation cephalosporin introduced in Japan as a treatment for a broad range of bacterial infections including dermatological and other community acquired infections. Cefditoren pivoxil is reported to have a broad spectrum of activity against both Gram-positive and Gramnegative bacteria, more potent than many other existing agents of its class. In particular, it shows the highest therapeutic activity against S. pneumoniae and S. marcescens infections. It exhibits resistance to β-lactamase hydrolysis typical of third generation cephalosporins. As a prodrug of cefditoren, it is readily absorbed through GI tract and has low toxicity and side effects.

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Cefditoren Pivoxil is an antibacterial and is a third generation cephalosporin.

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ChEBI: The pivaloyloxymethyl ester prodrug of cefditoren.

Antimicrobial activity

It exhibits good activity against staphylococci, streptococci (but not enterococci), H. influenzae and M. catarrhalis, including β-lactamase-producing strains. Isolates of Str. pneumoniae exhibiting reduced susceptibility to penicillin are less susceptible (MIC 0.125–2 mg/L). Most enterobacteria, including many Enterobacter, Citrobacter, Serratia and Proteus spp., are susceptible. It is not active against Ps. aeruginosa, Sten. maltophilia or atypical respiratory pathogens such as Chlamydophila pneumoniae and M. pneumoniae. It is stable to staphylococcal and common enterobacterial β-lactamases.

Pharmacokinetics

Oral absorption: c. 70%
Cmax 200 mg oral: c. 1.8 mg/L after 1.5–3 h
Plasma half-life: 0.8–1.3 h
Volume of distribution: 9.3 L
Plasma protein binding: 88%
After oral administration the pivaloyl ester is rapidly cleaved by esterases in the gut wall. Ingestion with food improves the bioavailability. Plasma concentrations are raised in elderly patients. There is no accumulation on repeated dosing.
It is excreted unchanged in the urine with a half-life of around 1.5 h, achieving a concentration of 150–200 mg/L within 4 h. Dosage adjustment is recommended in patients with deteriorating renal function.

Clinical Use

It has been advocated for community-acquired upper and lower respiratory tract infections and skin infections.

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In common with other pivoxil esters it may cause carnitine deficiency. Other side effects are those common to cephalosporins, mainly gastrointestinal disturbance.

Cefditoren pivoxil ?? ?? ? ???

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?????? 5-(4-METHYLPHENYL)-1,3,4-OXADIAZOLE-2-THIOL

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Cefditoren pivoxil ?? ??

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Watson Biotechnology Co.,Ltd	+86-18186686046	sales01@watsonbiotech.cn	China	5777	58
Shaanxi Xianhe Biotech Co., Ltd	+8617709210191	Jerry@xhobio.com	China	885	58
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
career henan chemical co	+86-0371-86658258 +8613203830695	sales@coreychem.com	China	29855	58
Cangzhou Wanyou New Material Technology Co.,Ltd	18631714998	sales@czwytech.com	CHINA	904	58
Shanghai Longyu Biotechnology Co., Ltd.	+8619521488211	info@longyupharma.com	China	2556	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49733	58
Hebei Runbin Biotechnology Co. LTD	13180553332	2179877681@qq.com	CHINA	990	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32301	58

Cefditoren pivoxil ?? ??: