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4-P-PDOT

4-P-PDOT ??? ???
?? ??:
134865-74-0
???:
4-P-PDOT
???(??):
AH-024;4-P-PDOT;4-P-PDOT, 10 mM in DMSO;4-PHENYL-2-PROPIONAMIDOTETRALIN;4-P-PDOT, MT2 selective melatonin receptor antagonist;N-(4-phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propanamide;N-(4-Phenyl-1,2,3,4-tetrahydronaphthalen-2-yl)propionamide;Propanamide, N-(1,2,3,4-tetrahydro-4-phenyl-2-naphthalenyl)-;4-P-PDOT; 4PPDOT; 4P-PDOT; AH-024; 4-PHENYL-2- PROPIONAMIDOTETRALIN.;Melatonin,Melatonin Receptor,GSSG,Nrf2,GSH,4PPDOT,ERK,memory,damage,Inhibitor,oxidative,4 P PDOT,MT2,inhibit
CBNumber:
CB7203987
???:
C19H21NO
??? ??:
279.38
MOL ??:
134865-74-0.mol
MSDS ??:
SDS

4-P-PDOT ??

???
166 °C
?? ?
480.1±45.0 °C(Predicted)
??
1.11±0.1 g/cm3(Predicted)
?? ??
room temp
???
Soluble in DMSO > 10 mM
?? ?? (pKa)
15.87±0.40(Predicted)
??? ??
??
??
???? ????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
RTECS ?? TX1498350
HS ?? 2924.29.7790
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P330 ?? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

4-P-PDOT C??? ??, ??, ??

???? ??

Melatonin receptor antagonist, >300-fold selective for the MT 2 (vs MT 1 ) subtype.

Biochem/physiol Actions

4-P-PDOT is a slelctive MT2 melatonin receptor antagonist 300 fold selective for MT2 (MEL-1B-R) vs MT1 (MEL-1A-R) melatonin receptor subtype.

4-P-PDOT ?? ?? ? ???

???

?? ??

4-P-PDOT ?? ??

???( 83)?? ??
??? ?? ??? ?? ?? ? ??
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4-P-PDOT ?? ??:

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