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MK 485

MK 485 ??? ???
?? ??:
28875-92-5
???:
MK 485
???(??):
MK 485;R-(+)-Carbidopa;Carbidopa Impurity 18;Carbidopa Impurity 12;(R)-carbidopa impurity control;Carbidopa Impurity 2 Trifluoroacetate;Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-a-methyl-, (R)-;Hydrocinnamic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, D- (8CI);Benzenepropanoic acid, α-hydrazino-3,4-dihydroxy-α-methyl-, (αR)-; (R)-3-(3,4-Dihydroxyphenyl)-2-hydrazineyl-2-methylpropanoic acid
CBNumber:
CB71270230
???:
C10H14N2O4
??? ??:
226.23
MOL ??:
28875-92-5.mol

MK 485 ??

???
>163°C (dec.)
?? ?
528.7±50.0 °C(Predicted)
??
1.420±0.06 g/cm3(Predicted)
?? ??
Hygroscopic, Refrigerator, under inert atmosphere
???
DMSO (?? ???), ???(?? ???,??, ??? ??)
?? ?? (pKa)
3.40±0.14(Predicted)
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??
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InChI
InChI=1/C10H14N2O4/c1-10(12-11,9(15)16)5-6-2-3-7(13)8(14)4-6/h2-4,12-14H,5,11H2,1H3,(H,15,16)/t10-/s3
InChIKey
TZFNLOMSOLWIDK-JQHDBZEONA-N
SMILES
[C@](C)(NN)(C(=O)O)CC1C=CC(O)=C(O)C=1 |&1:0,r|

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MK 485 C??? ??, ??, ??

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R-(+)-Carbidopa is an inhibitor of DOPA decarboxylase, which plays a significant role in the prevention of the conversion of L-DOPA (D533751) to dopamine (D533780). Studies has also indicated the inhibitory effects of towards L-DOPA in human liver prepns and as well as 5-hydroxytryptophan (H975700).

MK 485 ?? ?? ? ???

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MK 485 ?? ??

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