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N-(1-??-2-?????)??-2,3-????-5-?????????

N-(1-??-2-?????)??-2,3-????-5-?????????
N-(1-??-2-?????)??-2,3-????-5-????????? ??? ???
?? ??:
66644-81-3
???:
N-(1-??-2-?????)??-2,3-????-5-?????????
???(??):
N-(1-??-2-?????)??-2,3-????-5-?????????
???:
N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide
???(??):
VERALIPRIDE;LIR166;Velaripride;Veralipride, 10 mM in DMSO;N-[(1-Allyl-2-pyrrolidinyl)methyl]-5-sulphamoyl-2-veratramide;LIR 166,inhibit,Dopamine Receptor,Veralipride,Inhibitor,LIR-166;N-(1-Allyl-2-pyrrolidinyl)methyl-2,3-dimethoxy-5-sulfamoylbenzamide;N-[(1-Allylpyrrolidin-2-yl)methyl]-2,3-dimethoxy-5-sulfamoylbenzamide;2,3-diMethoxy-N-{[1-(prop-2-en-1-yl)pyrrolidin-2-yl]Methyl}-5-sulfaMoylbenzaMide;Benzamide, 5-(aminosulfonyl)-2,3-dimethoxy-N-[[1-(2-propen-1-yl)-2-pyrrolidinyl]methyl]-
CBNumber:
CB6306612
???:
C17H25N3O5S
??? ??:
383.46
MOL ??:
66644-81-3.mol

N-(1-??-2-?????)??-2,3-????-5-????????? ??

???
128 °C
??
1.230±0.06 g/cm3(Predicted)
?? ??
under inert gas (nitrogen or Argon) at 2-8°C
???
????? (?? ???), DMSO (?? ???)
??? ??
??
??? ??
??? ??
?? ?? (pKa)
10.02±0.60(Predicted)
??
???? ?????
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
HS ?? 2935.90.6000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
H312 ??? ???? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P280,P302+P352, P312, P322, P363,P501
H332 ???? ??? ?? ?? ?? ?? ?? 4 ?? GHS hazard pictograms P261, P271, P304+P340, P312
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P271 ?? ?? ??? ? ?? ???? ?????.
P280 ????/???/???/?????? ?????.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P302+P352 ??? ??? ??? ?? ????.
P304+P340 ???? ??? ??? ?? ??? ??? ???? ?? ??? ??? ????.
P312 ???? ??? ????(??)? ??? ????.
P322 ?? ??(??? … ??)
P330 ?? ?????.
P363 ?? ??? ??? ??? ?????.
P501 ...? ??? / ??? ?? ???.

N-(1-??-2-?????)??-2,3-????-5-????????? C??? ??, ??, ??

??

Labelled Veralipride, a synthetic benzamide derivative with antidopaminergic action, is effective in reducing the frequency and severity of hot flashes associated with menopausal hypoestrogenism, gain ing interest as a non-hormonal treatment for climacteric flushing.

N-(1-??-2-?????)??-2,3-????-5-????????? ?? ?? ? ???

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N-(1-??-2-?????)??-2,3-????-5-????????? ?? ??

???( 77)?? ??
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N-(1-??-2-?????)??-2,3-????-5-????????? ?? ??:

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