5-Lipoxygenase Polyclonal Antibody C??? ??, ??, ??
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5-Lipoxygenase (5-LO) is an enzyme encoded by
ALOX5 in humans that is involved in leukotriene biosynthesis. It is comprised of an N-terminal regulatory domain and a C-terminal catalytic domain and is primarily expressed in leukocytes. Increases in intracellular calcium levels or cellular stress induce translocation of 5-LO from the cytosol or nucleoplasm, depending on the cell type and 5-LO phosphorylation status, to the nuclear envelope, where it interacts with 5-LO-activating protein (FLAP), which transfers arachidonic acid (Item Nos.
90010 |
90010.1 |
10006607) to 5-LO. 5-LO catalyzes the conversion of arachidonic acid to 5(S)-HpETE and then to leukotriene A
4 (LTA
4). Other substrates of 5-LO include 5,8,11,14,17-eicosapentaenoic acid, 5,8,11-eicosatrienoic acid, 5,8-eicosadienoic acid, 12-HpETE, and 15-HpETE.
Alox5 knockout mice are protected against arthritis and pulmonary inflammation. Knockout of
Alox5 also protects apolipoprotein E-deficient hyperlipidemic mice from high-fat diet-induced hepatic injury and inflammation. Levels of 5-LO are elevated in postmortem hippocampus and cortex of patients with Alzheimer''s disease. Cayman''s 5-Lipoxygenase Polyclonal Antibody can be used for Western blot and immunohistochemistry applications. The antibody recognizes 5-LO at 78 kDa from human and porcine samples.
5-Lipoxygenase Polyclonal Antibody ?? ?? ? ???
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