1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione ??? ???
?? ??:
376382-11-5
???:
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione
???(??):
BRD 7389;BRD 7389
(BRD7389);BRD7389 >=98% (HPLC);BRD7389, 10 mM in DMSO;Insulin Expression Inducer, BRD7389;BRD-7389, p90 ribosomal S6 kinase RSK inhibitor;1-Phenethylamino-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-(Phenethylamino)-2H-naphtho[1,2,3-de]quinoline-2,7(3H)-dione;1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione;1-[(2-Phenylethyl)amino]-naphtho-3H-[1,2,3-de]quinoline-2,7-dione
CBNumber:
CB62518899
???:
C24H18N2O2
??? ??:
366.41
MOL ??:
376382-11-5.mol
MSDS ??:
SDS
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione ??
?? ?
655.0±55.0 °C(Predicted)
??
1.35±0.1 g/cm3(Predicted)
?? ??
Store at +4°C
???
DMSO: >20mg/mL
??? ??
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?? ?? (pKa)
11.31±0.40(Predicted)
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P- ??
H413
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1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione C??? ??, ??, ??
??
BRD7389 is an inhibitor of ribosomal S6 kinases (RSKs; IC
50 s = 1.5, 2.4, and 1.2 μM for RSK1, RSK2, and RSK3, respectively). Through this action, BRD7389 causes mouse αTC1 pancreatic α cells to adopt several morphological and gene expression features of β cells, including increased insulin expression. BRD7389 also enhances glucose-stimulated insulin and glucagon secretion by pancreatic islet cells isolated from human donors with a low body mass index.
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione ?? ?? ? ???
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1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione ?? ??
???( 53)?? ??
CHINA 40
United Kingdom 1
United States 11
USA 1
Global 53
1-[(2-Phenylethyl)amino]-3H-naphtho[1,2,3-de]quinoline-2,7-dione ?? ??: