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(R)-(+)-SKF-38393 hydrochloride

(R)-(+)-SKF-38393 hydrochloride ??? ???
?? ??:
81702-42-3
???:
(R)-(+)-SKF-38393 hydrochloride
???(??):
R-SKF-38393A HCl;R(+)-SKF-38393 HYDROCHLORIDE;RSKF38393A HCl,R SKF 38393A HCl;(R)-(+)-SKF38393 hydrochloride, D1 partial agonist
CBNumber:
CB62129530
???:
C16H17NO2.ClH
??? ??:
291.776
MOL ??:
81702-42-3.mol
MSDS ??:
SDS

(R)-(+)-SKF-38393 hydrochloride ??

???
244-246 °C
???
0.1M HCl: ???1.2mg/mL
??? ??
??
??? ??
??? ??
??
????? ?? ???
optical activity
[α]22/D +16.1°, c = 1.2 in methanol(lit.)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xi
?? ???? ?? 36/37/38
????? 26-36-22
WGK ?? 3
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

(R)-(+)-SKF-38393 hydrochloride C??? ??, ??, ??

??

(R)-(+)-SKF-38393 Hydrochloride is the active enantiomer of (±)-SKF-38393, a D1 dopamine receptor agonist.

Biochem/physiol Actions

(R)-(+)-SKF-38393 hydrochloride is a D1 dopamine receptor agonist and an active enantiomer of (±)-SKF-38393. It enhances pertussis toxin-insensitive and protein kinase A-mediated glutamate release in the hippocampal neurons. SKF-38393, a?benzazepine derivative, exhibits anorectic effects.

(R)-(+)-SKF-38393 hydrochloride ?? ?? ? ???

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(R)-(+)-SKF-38393 hydrochloride ?? ??

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