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AKT2 (AB-1) POLYCLONAL ANTIBODY

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AKT2 (AB-1) POLYCLONAL ANTIBODY
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akt3;Anti-STK-2;Anti-se20-9;Anti-pp12301;ANTI-PKBGAMMA;Anti-KIAA0204;Anti-MGC33171;Anti-bA16H23.1;ANTI-PROTEIN KINASE B;ANTI-AKT2 (AB-1), HUMAN
CBNumber:
CB6155869
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MOL ??:
Mol file

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STE20 like kinase (SLK) is a 1204 amino acid serine/threonine kinase. It possesses a kinase domain located at the amino-terminal and a C-terminal regulatory domain with coiled-coils. SLK is group V germinal center kinase that is expressed in the nucleus, cytosol, microtubules and centrosomes. The SLK gene is localized on human chromosome 10q24.33.

Biochem/physiol Actions

STE20 like kinase (SLK) is a modulator of cell motility. It phosphorylates cytoskeleton-bound proteins, which take part in the remodeling of migratory cell architecture. SLK is also involved in mitogen-activated protein kinase pathways. It acts as an activator of Jun N-terminal kinase (JNK) and transactivates tumor suppressor p53.

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