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1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)-

1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)- ??? ???
?? ??:
261769-44-2
???:
1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)-
???(??):
BMS-281384;BMS 281384,BMS281384;1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)-
CBNumber:
CB58738780
???:
C23H23ClN6O2
??? ??:
450.92
MOL ??:
261769-44-2.mol

1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)- ??

???
209-210.5 °C
?? ?
702.9±60.0 °C(Predicted)
??
1.34±0.1 g/cm3(Predicted)
?? ??
room temp
???
DMSO: 2mg/mL, clear (warmed)
?? ?? (pKa)
11.63±0.46(Predicted)
??? ??
powder
??
white to beige

??

1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)- C??? ??, ??, ??

Biochem/physiol Actions

BMS-281384 is a selective and potent phosphodiesterase 5 (PDE 5) inhibitor. BMS-281384 was found to have an IC50 value of 0.8 nM for PDE5 and 47 to 9200-fold selective over other PDEs 1-6.

1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)- ?? ?? ? ???

???

?? ??

1H-Pyrazolo[3,4-b]pyridine-5-carboxamide, 4-[[(3-chloro-4-methoxyphenyl)methyl]amino]-1-ethyl-N-(4-pyridinylmethyl)- ?? ??

???( 5)?? ??
??? ?? ??? ?? ?? ? ??
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