ENALAPRILAT DIHYDRATE
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ENALAPRILAT DIHYDRATE ??
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- 151-159°C
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- [α]D25 -53.0～-56.0゜ (c=1, CH3OH) (Calculated on dehydrous basis)
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- 2-8°C
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- H2O: 60°C?? ??? 14mg/mL(5?? ???? ??)
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- Solid
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- CAS ??????
- 84680-54-6(CAS DataBase Reference)
ENALAPRILAT DIHYDRATE C??? ??, ??, ??
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Angiotensin-converting enzyme (ACE) converts angiotensin I to angiotensin II, a peptide hormone that impacts vascular smooth muscle tone and renal salt exchange, driving hypertension. Enalaprilat is the active metabolite of enalapril , an ACE inhibitor with roles in the management of hypertension, congestive heart failure, myocardial infarction, and diabetic nephropathies.. Enalaprilat is esterified with ethanol to produce enalapril in order to enable oral activity and subsequently metabolized in vivo to the active form by various esterases. Enalaprilat is reported to inhibit ACE activity with an IC50 value of 5.8 nM in vitro.??? ??
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ChEBI: The dihydrate form of enalaprilat, an angiotensin-converting enzyme (ACE) inhibitor that is used (often in the form of its prodrug, enalapril) in the treatment of hypertension and heart failure, for reduction of proteinuria and renal disease in patients wi h nephropathies, and for the prevention of stroke, myocardial infarction, and cardiac death in high-risk patients. Unlike enalapril, enalaprilat is not absorbed by mouth but is administered by intravenous injection.ENALAPRILAT DIHYDRATE ?? ?? ? ???
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ENALAPRILAT DIHYDRATE ?? ??
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| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
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| AFINE CHEMICALS LIMITED | +86-0571-85134551 |
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ENALAPRILAT DIHYDRATE ?? ??:
Enalaprilat
Triphosgene
Ethyl trans-3-Benzoylacrylate
Enalapril EP IMpurity A (SSR)
L-Proline
(R,S,S)-Enalapril
L-Alanine
Enalapril diketopiperazine
(αS)-Cyclohexanebutanoic Acid α-[[(1S)-1-Carboxyethyl]aMino]
cyclohexanebutanoic Acid α-Ethyl Ester
Ethyl 3-benzoylacrylate
Phenylsilane
CHLOROPHENYLSILANE 97
Dimethylimidazole
Phenyltrichlorosilane
MOEXIPRIL HYDROCHLORIDE
Fosinopril sodium
CILAZAPRIL
Belinostat (PXD101)