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2-N-??-4-????

2-N-??-4-????
2-N-??-4-???? ??? ???
?? ??:
96017-59-3
???:
2-N-??-4-????
???(??):
2-N-??-4-????
???:
2-N-HEXYL-4-PENTYNOIC ACID
???(??):
Hexyl-4-pentynoic Acid;2-Hexyl-4-pentynoic Acid;2-PROPARGYLOCTANOIC ACID;2-Hexyl-4-pentynoicAcid>2-N-HEXYL-4-PENTYNOIC ACID;2-(2-PROPYNYL)OCTANOIC ACID;Hexyl-4-pentynoic acid (HPA);R-2-(2-propynyl)octanoic acid;2-(2-Propyn-1-yl)octanoic Acid;2-(Prop-2-yn-1-yl)octanoic acid
CBNumber:
CB5317246
???:
C11H18O2
??? ??:
182.26
MOL ??:
96017-59-3.mol

2-N-??-4-???? ??

?? ?
287.1±23.0 °C(Predicted)
??
0.94
???
1.4450-1.4510
?? ??
Inert atmosphere,Room Temperature
???
DMSO(?? 25mg/ml) ?? ???(?? 25mg/ml)? ?????.
?? ?? (pKa)
4.24±0.21(Predicted)
??? ??
??
??
???
???
??? ?? ?????? 2? ?? ??????. DMSO ?? ??? ??? -20°C?? ?? 3?? ?? ??? ? ????.
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
??? ?? Xn
?? ???? ?? 22
HS ?? 2916.19.3000
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 2A ?? GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P280 ????/???/???/?????? ?????.
NFPA 704
0
2 0

2-N-??-4-???? C??? ??, ??, ??

??

2-hexyl-4-Pentynoic acid is a derivative of valproic acid , an inhibitor of histone deacetylases (HDACs). It inhibits HDAC activity more potently (IC50 = 13 μM) than valproic acid (IC50 = 398 μM). 2-hexyl-4-Pentynoic acid induces histone hyperacetylation in cerebellar granule cells significantly at 5 μM. It also induces the expression of heat shock proteins Hsp70-1a and Hsp70-1b and protects cerebellar granule cells from glutamate-induced excitotoxicity when used at a concentration of 50 μM.

2-N-??-4-???? ?? ?? ? ???

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2-N-??-4-???? ?? ??

???( 51)?? ??
??? ?? ??? ?? ?? ? ??
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