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(S)-4-HydroxyMethyl AMbrisentan

(S)-4-HydroxyMethyl AMbrisentan ??? ???
?? ??:
1106685-66-8
???:
(S)-4-HydroxyMethyl AMbrisentan
???(??):
PDUAYPFMBRYSNN-LJQANCHMSA-N;(S)-4-Hydroxymethyl Ambrisentan;Ambrisentan 4-Hydroxymethyl Analog;4-Hydroxy Methyl Ambrisentan(Ambrisentan Impurity 15);(S)-2-((4-(Hydroxymethyl)-6-methylpyrimidin-2-yl)oxy)-3-methoxy-3,3-diphenylpropanoic acid;Benzenepropanoic acid, α-[[4-(hydroxymethyl)-6-methyl-2-pyrimidinyl]oxy]-β-methoxy-β-phenyl-, (αS)-
CBNumber:
CB52709894
???:
C22H22N2O5
??? ??:
394.43
MOL ??:
1106685-66-8.mol

(S)-4-HydroxyMethyl AMbrisentan ??

???
>130oC (dec.)
?? ?
600.0±60.0 °C(Predicted)
??
1.291±0.06 g/cm3(Predicted)
?? ??
Hygroscopic, -20°C Freezer, Under inert atmosphere
???
DMSO(?? ???), ???(?? ???)
?? ?? (pKa)
1.74±0.10(Predicted)
??? ??
??
??? ??
??? ??
??
???

??

(S)-4-HydroxyMethyl AMbrisentan C??? ??, ??, ??

??

(S)-4-Hydroxymethyl Ambrisentan is a metabolite of Ambrisentan (A575860), a nonpeptide endothelin ETA receptor antagonist. Antihypertensive.

(S)-4-HydroxyMethyl AMbrisentan ?? ?? ? ???

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(S)-4-HydroxyMethyl AMbrisentan ?? ??

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