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Naftifine

Naftifine ??? ???
?? ??:
65472-88-0
???:
Naftifine
???(??):
Naftin;naftifin;Exoderil;NAFTIFINE;AW-105-843;SN-105-843;Naftifungin;Naftifine D3;Naftifinebase;Naftifine 13CD3
CBNumber:
CB5211922
???:
C21H21N
??? ??:
287.4
MOL ??:
65472-88-0.mol

Naftifine ??

???
177 °C
?? ?
bp0.015 torr 162-167°
??
1.082±0.06 g/cm3(Predicted)
???
Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Very Slightly)
??? ??
??? ??
?? ?? (pKa)
7.99±0.50(Predicted)
??
??~?? ???
Merck
6355
CAS ??????
65472-88-0(CAS DataBase Reference)

??

HS ?? 29214990

Naftifine C??? ??, ??, ??

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Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.

Indications

Naftifine (Naftin) is a synthetic allylamine derivative topical antifungal agent that works by blocking squalene 2,3-epoxidase, resulting in increased cell membrane permeability and cell death. It is structurally and pharmacologically related to terbinafine. It also has some antiinflammatory properties that may be due to its ability to alter chemotaxis by polymorphonucleocytes. It is most effective against dermatophytes, moderately active against molds, and less active against yeasts, including C. albicans.

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ChEBI: A tertiary amine in which the nitrogen is substituted by methyl, alpha-naphthylmethyl, and (1E)-cinnamyl groups. It is used (usually as its hydrochloride salt) for the treatment of fungal skin infections.

Antimicrobial activity

Naftifine is fungicidal against dermatophytes such as Epidermophyton floccosum, Trichophyton and Microsporum species. Against pathogenic yeasts such as Candida species and moulds, it shows only an intermediate fungistatic activity in vitro.

Pharmaceutical Applications

A topical antifungal used as a 1% cream for the treatment of dermatophytoses, including tinea pedis, tinea corporis and tinea cruris.

Clinical Use

Naftifine was the first allyl amine to be discovered and marketed. It is subject to extensive first-pass metabolism to be orally active and, consequently, is only available in topical preparations. The widest use of naftifine is against various tinea infections of the skin.

Naftifine ?? ?? ? ???

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