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Protopanaxadiol

Protopanaxadiol ??? ???
?? ??:
7755-01-3
???:
Protopanaxadiol
???(??):
Protopanaxadiol;20R-Protopanaxadiol;(20R)-Protopanaxadiol;20R-Betulafolienetriol;Protopanaxadiol USP/EP/BP;PROTOVERATRINE A+B (RG)(CALL);(20R)-Dammar-24-ene-3β,12β,20-triol;(20R)-Protopanaxadiol, 10 mM in DMSO;(20R)-5α-Dammar-24-ene-3β,12β,20-triol;Dammar-24-ene-3,12,20-triol, (3β,12β,20R)-
CBNumber:
CB51040709
???:
C30H52O3
??? ??:
460.73
MOL ??:
7755-01-3.mol

Protopanaxadiol ??

?? ?
559.5±40.0 °C(Predicted)
??
1.036±0.06 g/cm3(Predicted)
?? ??
Sealed in dry,2-8°C
???
Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
??? ??
??
?? ?? (pKa)
14.96±0.70(Predicted)
??
???
LogP
7.590 (est)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictograms
?? ?: Warning
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H302 ??? ??? ?? ?? ?? - ?? ?? 4 ?? GHS hazard pictograms P264, P270, P301+P312, P330, P501
??????:
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P301+P312 ??? ???? ??? ????(??)? ??? ????.
P330 ?? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

Protopanaxadiol C??? ??, ??, ??

??

(20)R-Protopanaxadiol is a sapogenin that has been found in P. ginseng and has anticancer and antibacterial activities. It has a cytotoxic concentration (CC50) value of 6.1 μM in MT-4 human T cell leukemia cells and inhibits the growth of several additional cancer cell lines, including A549 human lung carcinoma, SKOV3 human ovarian adenocarcinoma, SK-Mel-2 human melanoma, P388 and L1210 murine leukemia, and K562 human chronic leukemia cells (ED50s = 11-26 μM). (20)R-protopanaxadiol also inhibits the growth of H. pylori in vitro (MICs = 50-100 μg/ml).

??

20(R)-Protopanaxdiol is a saponin ginsenoside which is a signature phytochemical of Ginseng, an herbaceous plant. Anti-cancer agent.

??

ChEBI: A diastereomer of protopanaxadiol in which the 20-hydroxy substituent has been introduced at the pro-R position.

Protopanaxadiol ?? ?? ? ???

???

20(R)-Ginsenoside Rg3

?? ??

Protopanaxadiol ?? ??

???( 118)?? ??
??? ?? ??? ?? ?? ? ??
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Protopanaxadiol ?? ??:

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