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????II

????II
????II ??? ???
?? ??:
500735-47-7
???:
????II
???(??):
????II
???:
OLOMOUCINE II
???(??):
Nsc736738;Olomoucine II, CDK/cyclin inhibitor;Olomoucine II - CAS 500735-47-7 - Calbiochem;Olomoucine ii, 6-[(2-hydroxybenzyl)amino]-2-[1-(hydroxymethyl)propylamino]- 9-isopropylpurine;2-[[[2-[[(1R)-1-(Hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]phenol;Phenol, 2-[[[2-[[(1R)-1-(hydroxymethyl)propyl]amino]-9-(1-methylethyl)-9H-purin-6-yl]amino]methyl]-
CBNumber:
CB4504061
???:
C19H26N6O2
??? ??:
370.45
MOL ??:
500735-47-7.mol
MSDS ??:
SDS

????II ??

?? ?
618.5±65.0 °C(Predicted)
??
1.32
?? ??
−20°C
???
?????: 50mg/mL, ???
??? ??
??
?? ?? (pKa)
9.83±0.30(Predicted)
??
colorless

??

????? 22-24/25
WGK ?? 3

????II C??? ??, ??, ??

?? ??

A cell-permeable 2,6,9-trisubstituted purine analog that acts as a potent, reversible, and ATP-competitive inhibitor of Cdk1/B with an IC50 of 20 nM and displays increased potency over purvalanol A (Cat. No. 540500; IC50 = 50 nM), Roscovitine (Cat. No. 557360; IC50 = 450 nM), Bohemine (Cat. No. 203600; IC50 = 1.1 μM) and Olomoucine (Cat. No. 495620; IC50 = 7.0 μM). Further, exerts greater in vitro cytotoxicity in various cancer cell lines (IC50 = 3.0 μM, 5.3 μM, 6.3 μM, 6.3 μM and 11.1 μM for CEM, MCF7, HOS, G631 and K562, respectively).

Biochem/physiol Actions

Cell permeable: yes

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