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1208313-97-6
???:
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???(??):
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???:
Ketone Ester
???(??):
(R)-3-hydroxybutyl (R)-3-hydroxybutyrate;[(3R)-3-hydroxybutyl] (3R)-3-hydroxybutanoate;R-BHB;BD-AcAc 2;Ketone Ester;Ketone Ester (R-BHB);(R)-(R)-3-hydroxybutyl 3-hydroxybutanoate;Ketone ester D-BHB R-BHB Beta-hydroxybutyrate;(3R)-3-Hydroxybutanoic acid (3R)-3-hydroxybutyl ester;Butanoic acid, 3-hydroxy-, (3R)-3-hydroxybutyl ester, (3R)-
CBNumber:
CB42628004
???:
C8H16O4
??? ??:
176.21
MOL ??:
1208313-97-6.mol

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269℃
??
1.102
???
101℃
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Store at -20°C
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Methyl Acetate: 50 mg/ml
?? ?? (pKa)
14.38±0.20(Predicted)
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Liquid
??
Colorless to light yellow
InChI
InChI=1S/C8H16O4/c1-6(9)3-4-12-8(11)5-7(2)10/h6-7,9-10H,3-5H2,1-2H3/t6-,7-/m1/s1
InChIKey
AOWPVIWVMWUSBD-RNFRBKRXSA-N
SMILES
C(OCC[C@H](O)C)(=O)C[C@H](O)C

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Ketone ester is exogenous ketone bodies that may promote ketosis in humans. Studies on animals have shown that ketone esters can have positive effects on Alzheimer's disease by decreasing amyloid buildup, reducing neurofibrillary tangles and tau, and enhancing learning and memory.

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Ketone ester can be prepared by reacting (3R)-3-hydroxybutyl methyl ester with tert-butyl dimethylchlorosilane.
Synthesis of Ketone ester

benefits

Ketone esters can help with muscle recovery after exercising. They increase the rate of energy store replenishment in the body and support the process of rebuilding muscles. They also decrease the amount of muscle breakdown. The various forms of ketone esters that have been utilized include R,S-1,3-butanediol diacetoacetate (BD-AcAc2, ketone diester), D-β-hydroxybutyrate-(R)-1,3 butanediol (ketone monoester), and Bis-hexanoyl (R)-1,3-butanediol (BH-BD), among others.?

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Ketone ester–enriched diets that induce sustained ketonemia reduce pathological cardiac remodeling and enhance ventricular function in multiple heart failure models across both mice and rats using both prevention and treatment strategies.

Safety

Taking ketone supplements can cause extreme stomach upset in some people. This side effect can limit the number of supplements that a person can take. Taking ketone salts also increases the risk of electrolyte imbalances. Electrolytes are vital for the conduction of electrical signals in the muscles and neurons.

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