ChemicalBook >?? ???? >???,L-γ-????-S-(???????)-L-?????-

???,L-γ-????-S-(???????)-L-?????-

???,L-γ-????-S-(???????)-L-?????- ??? ???

?? ??:: 69819-86-9

???:: ???,L-γ-????-S-(???????)-L-?????-

???(??):: ???,L-γ-????-S-(???????)-L-?????-

???:: Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-

???(??):: Darinaparsin;SP02);ZIO 101;EOS-60608;Selurampanel;Darinaparsin (ZIO101;Dimethylarsinic glutathione;Glycine, L-γ-glutaMyl-S-(diMethylarsino)-L-cysteinyl-

CBNumber:: CB42563431

???:: C12H22AsN3O6S

??? ??:: 411.3

MOL ??:: 69819-86-9.mol

?? ?? 28

???,L-γ-????-S-(???????)-L-?????- ??

?? ??: Store at -20°C

???: DMSO:10.0(Max Conc. mg/mL);24.31(Max Conc. mM)

??? ??: ??? ??

?? ?? (pKa): 2.21±0.10(Predicted)

??: White to off-white

?? ? ?? ??
?? ? ???? ?? (GHS)

????(GHS):

?? ?:

Warning

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	P- ??
H302	??? ???	?? ?? ?? - ??	?? 4	??	P264, P270, P301+P312, P330, P501
H315	??? ??? ???	????? ?? ?????	?? 2	??	P264, P280, P302+P352, P321,P332+P313, P362
H319	?? ?? ??? ???	?? ? ?? ?? ??? ??	?? 2A	??	P264, P280, P305+P351+P338,P337+P313P
H335	?? ???? ??? ? ??	?? ???? ?? - 1? ??;???? ??	?? 3	??

??????:

P261	??·?·??·???·??·...·????? ??? ????.
P280	????/???/???/?????? ?????.
P301+P312	??? ???? ??? ????(??)? ??? ????.
P302+P352	??? ??? ??? ?? ????.
P305+P351+P338	?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.

NFPA 704

	0
4		0

???,L-γ-????-S-(???????)-L-?????- C??? ??, ??, ??

??

Darinaparsin is a dimethylated arsenic linked to glutathione. It is cytotoxic to DU145, LNCaP, and PC3 prostate cancer cells (IC₅₀s = 5-10 μM) and patient-derived primary prostate cancer cells (IC₅₀s = 2.5-20 μM), as well as Jurkat T cell lymphoma and L540 Hodgkin lymphoma cells (IC₅₀s = 2.7 and 1.3 μM, respectively). It decreases the tumor-initiating subpopulation in DU145 and PC3 cells and halts the cell cycle in the G₂/M phase. Darinaparsin decreases transcription of Gli-2, a transcription factor that mediates Sonic hedgehog signaling, when used at a concentration of 1.5 but not 3 μM. It decreases SHP1 phosphatase activity and increases ERK phosphorylation. Darinaparsin reduces tumor growth in DU145 and PC3 prostate cancer mouse xenograft models when administered at a dose of 100 mg/kg every other day.

???,L-γ-????-S-(???????)-L-?????- ?? ?? ? ???

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???,L-γ-????-S-(???????)-L-?????- ?? ??

???( 28)?? ??

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