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?????????III

?????????III
?????????III ??? ???
?? ??:
879127-16-9
???:
?????????III
???(??):
?????????III
???:
Aurora Kinase Inhibitor III
???(??):
AKI-7169;Aurora Kinase Inhibitor 3;Aurora Kinase Inhibitor III;AKI-7169(Aurora Kinase Inhibitor III);Aurora Kinase Inhibitor III - CAS 879127-16-9 - Calbiochem;N-[3-[[4-[3-(trifluoromethyl)anilino]pyrimidin-2-yl]amino]phenyl]cyclopropanecarboxamide;N-(3-((4-((3-(Trifluoromethyl)phenyl)amino)pyrimidin-2-yl)amino)phenyl)cyclopropanecarboxamide;Cyclopropanecarboxamide, N-[3-[[4-[[3-(trifluoromethyl)phenyl]amino]-2-pyrimidinyl]amino]phenyl]-;Cyclopropanecarboxylic acid {3-[4-(3-trifluoromethyl-phenylamino)-pyrimidin-2-ylamino]-phenyl}-amide;Aurora Kinase,Aurora kinase inhibitor 3,Aurora kinase inhibitor3,Inhibitor,Aurora kinase inhibitor-3,inhibit
CBNumber:
CB42098016
???:
C21H18F3N5O
??? ??:
413.4
MOL ??:
879127-16-9.mol
MSDS ??:
SDS

?????????III ??

??
1.456±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
H2O: <2mg/mL
?? ?? (pKa)
14.51±0.70(Predicted)
??? ??
?? ??
??
???
???
H2O: <2mg/mL
DMSO: >7mg/mL

??

WGK ?? 3

?????????III C??? ??, ??, ??

?? ??

A cell-permeable 2,4-dianilinopyrimidine compound that acts as an ATP-competitive, potent, but non-selective inhibitor of Aurora A (IC50 = 42 nM). At higher concentrations, also inhibits the activities of other kinases, such as Lck, Bmx, IGF-1R, and Syk (IC50 = 131, 386, 591, and 887 nM, respectively).

Biochem/physiol Actions

Target IC50: 42 nM against Aurora A; 131, 386, 591, and 887 nM, against Lck, Bmx, IGF-1R, and Syk , respectively

?????????III ?? ?? ? ???

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?????????III ?? ??

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