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13,14-DIHYDRO-15-?????????E1

13,14-DIHYDRO-15-?????????E1
13,14-DIHYDRO-15-?????????E1 ??? ???
?? ??:
5094-14-4
???:
13,14-DIHYDRO-15-?????????E1
???(??):
13,14-DIHYDRO-15-?????????E1
???:
13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1
???(??):
U 21002;13,14-dihydro-15-keto PGE1;CDUVSQMTLOYKTR-ZHALLVOQSA-N;13,14-DIHYDRO-15-KETO PROSTAGLANDIN E1;9,15-dioxo-11α-hydroxy-prostan-1-oic acid;9,15-DIOXO-11ALPHA-HYDROXY-PROSTAN-1-OIC ACID;Prostan-1-oic acid, 11-hydroxy-9,15-dioxo-, (11α)-;15-Keto Prostaglandin E0 DISCONTINUED, OFFER K202056
CBNumber:
CB4190392
???:
C20H34O5
??? ??:
354.49
MOL ??:
5094-14-4.mol

13,14-DIHYDRO-15-?????????E1 ??

?? ?
537.2±35.0 °C(Predicted)
??
1.072±0.06 g/cm3(Predicted)
?? ??
-20°C Freezer, Under inert atmosphere
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DMSO (?? ???), ??? (?? ???), THF (?? ???)
??? ??
??
?? ?? (pKa)
4.77±0.10(Predicted)
??
?? ???

??

13,14-DIHYDRO-15-?????????E1 C??? ??, ??, ??

??

13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity. Steady state plasma concentrations are about 10 pg/ml. 13,14-dihydro-15-keto PGE1 is a weak inhibitor of ADP-induced platelet aggregation in human PRP and washed platelets with IC50 values of 54 and 200 μM, respectively, compared to PGE1 which has an IC50 of 40 nM.

??

15-Keto Prostaglandin E0 is a metabolite of Prostaglandin E1 (P838600) and has been shown to induce arterial thromboresistance in experimental animals and in man, but with several magnitudes higher concentrations than Prostaglandin E1. 15-Keto Prostaglandin E0 is also used as the active ingredient in compositions used for the treatment of external secretion disorders.

13,14-DIHYDRO-15-?????????E1 ?? ?? ? ???

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13,14-DIHYDRO-15-?????????E1 ?? ??

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