ChemicalBook >?? ???? >2-???-4-??????
2-???-4-??????
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2-???-4-?????? ??
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- 113.0 to 117.0 °C
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- 347.4±30.0 °C(Predicted)
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- 1.285±0.06 g/cm3(Predicted)
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- under inert gas (nitrogen or Argon) at 2-8°C
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- powder to crystal
- ?? ?? (pKa)
- 0.24±0.30(Predicted)
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- White to Orange to Green
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| HS ?? | 2933998090 |
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2-???-4-?????? C??? ??, ??, ??
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2-Chloro-4-phenylquinazoline acts as a reagent in the synthesis of MTH1 inhibitors that are potential cancer eradicators.Synthesis
A 2 L flask was charged with 35.0 g (175.8 mmol) of 2,4-dichloroquinoline,22.5 g (184.6 mmol) of phenylboronic acid, 6.1 g (5.3 mmol) of tetrakis(triphenylphosphine)palladium(0) were added to 800 mL of tetrahydrofuran and 400 mL of water, and the mixture was heated to 60 ?? C for 12 hours under a nitrogen stream. . The resulting mixture was added to methanol (3000 mL), and the crystallized solid was filtered and dissolved in toluene, filtered through silica gel / celite, and the organic solvent was removed in an appropriate amount, and then recrystallization from methanol gave Intermediate I-A52-1 (36.8 g, 87% yield).
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