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?????A

?????A
?????A ??? ???
?? ??:
75731-43-0
???:
?????A
???(??):
?????A
???:
marcfortine A
???(??):
UK 111866;marcfortine A;Spiro[4H,8H-[1,4]dioxepino[2,3-g]indole-8,2'(3'H)-[1H,4H-3a,9a](iminomethano)cyclopenta[b]quinolizine]-9,11'(10H)-dione, 6',7',8',9',10',10'a-hexahydro-1',1',4,4,12'-pentamethyl-, (2'R,3'aS,9'aS,10'aS)-
CBNumber:
CB41323193
???:
C28H35N3O4
??? ??:
477.602
MOL ??:
75731-43-0.mol

?????A ??

???
245 °C
?? ?
660.6±55.0 °C(Predicted)
??
1.33±0.1 g/cm3(Predicted)
?? ??
Store at -20°C
???
??? ? ???
??? ??
??
?? ?? (pKa)
12.05±0.60(Predicted)

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Marcfortine A is an indole alkaloid originally isolated from P. roqueforti. It has nematocidal activity against the parasitic nematode H. contortus (LD99 = 0.06 μg/ml) and inhibits motility of adult worms (EC50 = 2 μM)., Marcfortine A eliminates H. contortus, T. colubriformis, and O. ostertagi from experimentally infected jirds (ED95s = 0.33, 0.11, and 2.5 mg/animal, respectively). It dose-dependently inhibits nicotine-induced calcium mobilization in SH-SY5Y and TE-671 cells expressing α3 subunit-containing human nicotinic acetylcholine receptors (nAChRs) and muscle-type nAChRs, respectively.

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Marcfortine A is an indole alkaloid, isolated from Aspergillus and Pencillium species, with potent nematocidal activity. The marcfortines are structurally related to paraherquamides and are thought to act by blocking cholinergic neuromuscular transmission.

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