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4-?????-6,7-?????????

4-?????-6,7-????????? ??? ???

?? ??:: 21561-09-1

???:: 4-?????-6,7-?????????

???(??):: 4-?????-6,7-?????????

???:: 4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE

???(??):: WHI-P258;WHI-P258, 10 mM in DMSO;JAK3 INHIBITOR, NEGATIVE CONTROL;4-PHENYLAMINO-6,7-DIMETHOXYQUINAZOLINE;6,7-DIMETHOXY-N-PHENYL-4-QUINAZOLINAMINE;6,7-dimethoxy-N-phenylquinazolin-4-amine;4-Quinazolinamine, 6,7-dimethoxy-N-phenyl-;N-(6,7-DIMETHOXY-4-QUINAZOLINYL)-N-PHENYLAMINE;JAK3 INHIBITOR NEGATIVE CONTROL;WHIP258;WHI P258;WHI P258,WHI-P258,inhibit,Inhibitor,JNK,WHI-P-258,WHIP258

CBNumber:: CB3348071

???:: C16H15N3O2

??? ??:: 281.31

MOL ??:: Mol file

?? ?? 79

4-?????-6,7-????????? ??

?? ?: 441.2±40.0 °C(Predicted)

??: 1?+-.0.06 g/cm3(Predicted)

?? ??: Store at -20°C

???: DMF: 25 mg/ml; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 15 mg/ml

??? ??: ??? ??

?? ?? (pKa): 6.19±0.70(Predicted)

??: White to off-white

?? ? ?? ??

????(GHS):

?? ?:

??·?? ??:

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NFPA 704

	1
2		0

4-?????-6,7-????????? C??? ??, ??, ??

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WHI-P258 is a quinazoline compound that modeling studies suggested would bind to the active site of JAK3 with an estimated K_i value of 72 μM. However, it is inactive at JAK3 (IC₅₀ = >300 μM) and has been used as a negative control for structurally similar compounds that inhibit platelet aggregation and herpes simplex virus 1 (HSV-1) replication.

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4-Phenylamino-6,7-dimethoxyquinazoline is a specific inhibitors of Janus kinase 3 (JAK3).

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???	??	???	??	?? ?	??
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
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VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64

4-?????-6,7-????????? ?? ??:

4-(3'-HYDROXYPHENYL)AMINO-6,7-DIMETHOXYQUINAZOLINE, HCL WEHI-345 JAK3 INHIBITOR I 4-AMINO-3-CYANO-1,2,5,6-TETRAHYDROPYRIDINE WH-4-023 7-BROMO-1,2,3,4-TETRAHYDRO-QUINOLINE HYDROCHLORIDE WHI-P97 JAK3 Inhibitor Phenol, 3-[(6,7-diMethoxy-4-quinazolinyl)aMino]-

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