T5601640
T5601640 ??? ???
?? ??:
924473-59-6
???:
T5601640
???(??):
T5601640;T56-LIMKi;T56-LIMKi - T5601640;T-5601640(T56-LIMKi);T5601640;T 5601640;T56-LIMKI;3-Methyl-N-(3-((3-(trifluoromethyl)phenyl)carbamoyl)phenyl)isoxazole-5-carboxamide;3-methyl-N-[3-[[3-(trifluoromethyl)phenyl]carbamoyl]phenyl]-1,2-oxazole-5-carboxamide;3-Methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-5-isoxazolecarboxamide;5-Isoxazolecarboxamide, 3-methyl-N-[3-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]phenyl]-;T-56-LIMKi,T56LIMKi,inhibit,T56-LIMKi,T 5601640,LIM Kinase (LIMK),LIMKs,T-5601640,Inhibitor,T56 LIMKi
CBNumber:
CB33163675
???:
C19H14F3N3O3
??? ??:
389.33
MOL ??:
924473-59-6.mol
T5601640 ??
?? ?
403.4±45.0 °C(Predicted)
??
1.426±0.06 g/cm3(Predicted)
?? ??
2-8°C
???
DMF: 30 mg/ml; DMF:PBS(pH7.2) (1:2): 0.33 mg/ml; DMSO: 20 mg/ml
?? ?? (pKa)
11.41±0.70(Predicted)
??? ??
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?? ? ???? ?? (GHS)
????(UN No.)
UN 2811 6.1 / PGIII
????(GHS):
?? ?:
Danger
??·?? ??:
??
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??
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P- ??
H301 ??? ???
?? ?? ?? - ??
?? 3
??
P264, P270, P301+P310, P321, P330,P405, P501
H413 ??? ??? ?? ????? ??? ??? ??
?? ????? ?? - ??
?? 4
??????:
T5601640 C??? ??, ??, ??
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T 5601640 is a LIMK inhibitor and is used for the treatment of proliferative disorders such as cancer, neurofibromatosis and neuronal differentiation associated disaeses.
Biochem/physiol Actions
T56-LIMKi is a LIMK2 inhibitor that reduces phosphorylated cofilin, and induces disassembly of actin stress fibers in NF1-/- MEFs cells.
T5601640 ?? ?? ? ???
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T5601640 ?? ??
???( 58)?? ??
China 46
United Kingdom 1
United States 10
USA 1
Global 58
