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BMS813160

BMS813160 ??? ???
?? ??:
1286279-29-5
???:
BMS813160
???(??):
CS-2742;BMS813160;BMS-585059;BMS-813160, 10 mM in DMSO;BMS-813160;BMS813160;BMS 813160;N-((1R,2S,5R)-5-(tert-butylamino)-2-((S)-3-(7-tert-butylpyrazolo[1,5-a][1,3,5]triazin-4-ylamino)-2-oxopyrrolidin-1-yl)cyclohexyl)acetamide;Inhibitor,CC chemokine receptor,CCR,dual antagonist,peritonitis,CD11b,BMS-813160,inflammation,CTX,thioglycollate,BMS813160,inhibit,mouse,oral;Acetamide, N-[(1R,2S,5R)-5-[(1,1-dimethylethyl)amino]-2-[(3S)-3-[[7-(1,1-dimethylethyl)pyrazolo[1,5-a]-1,3,5-triazin-4-yl]amino]-2-oxo-1-pyrrolidinyl]cyclohexyl]-
CBNumber:
CB23364411
???:
C25H40N8O2
??? ??:
484.64
MOL ??:
1286279-29-5.mol

BMS813160 ??

??
1.31±0.1 g/cm3(Predicted)
?? ??
4°C, protect from light
???
DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM)
??? ??
??? ??
?? ?? (pKa)
15.46±0.60(Predicted)
??
White to off-white
InChIKey
CMVHFGNTABZQJU-HCXYKTFWSA-N
SMILES
C(N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC2N3N=C(C(C)(C)C)C=C3N=CN=2)C1=O)(=O)C
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
????(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H315 ??? ??? ??? ????? ?? ????? ?? 2 ?? GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H318 ?? ?? ??? ??? ?? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P280, P305+P351+P338, P310
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
H335 ?? ???? ??? ? ?? ?? ???? ?? - 1? ??;???? ?? ?? 3 ?? GHS hazard pictograms
H341 ???? ??? ??? ??? ??? (????? ???? ????? ???? ???? ???? ??? ?? ????? ??? ???? ??) ???? ???? ?? ?? 2 ?? P201,P202, P281, P308+P313, P405,P501
H361 ?? ?? ????? ??? ??? ??? ??? ???? ?? ?? 2 ?? P201, P202, P281, P308+P313, P405,P501
H370 ??(??, ??? ?? ??? ?? ??? ??)? ??? ???(????? ?? ???? ??? ???? ???? ???? ????? ??? ????? ??) ?? ???? ?? - 1? ?? ?? 1 ?? GHS hazard pictograms P260, P264, P270, P307+P311, P321,P405, P501
H413 ??? ??? ?? ????? ??? ??? ?? ?? ????? ?? - ?? ?? 4
??????:
P201 ?? ? ?? ???? ?????.
P202 ?? ?? ?? ??? ?? ???? ??? ???? ???.
P260 ??·?·??·???·??·...·????? ???? ???.
P264 ?? ??? ?? ??? ????.
P264 ?? ??? ?? ??? ????.
P270 ? ??? ??? ??? ???, ???? ???? ???.
P272 ??? ??? ??? ??? ???? ???.
P273 ???? ???? ???.
P280 ????/???/???/?????? ?????.
P284 ?? ???? ?????.
P302+P352 ??? ??? ??? ?? ????.
P304+P341 ???? ??,??? ??? ?? ??? ??? ??? ?? ??? ??? ???? ?? ??? ??? ??? ?
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
P308+P313 ?? ?? ??? ???? ???? ??· ??? ????.
P310 ?? ????(??)? ??? ????. ???? ?? ????(??)? ??? ????.
P321 (…) ??? ???.
P333+P313 ????? ?? ??? ???? ???? ??·??? ????.
P342+P311 ??? ??? ???? ????(??)? ??? ????.
P363 ?? ??? ??? ??? ?????.
P405 ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
3 0

BMS813160 C??? ??, ??, ??

??

BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.

BMS813160 ?? ?? ? ???

???

?? ??


BMS813160 ?? ??

???( 66)?? ??
??? ?? ??? ?? ?? ? ??
ATK CHEMICAL COMPANY LIMITED
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TargetMol Chemicals Inc.
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InvivoChem
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TargetMol Chemicals Inc.

support@targetmol.com United States 38672 58
Wuhan Topule Biopharmaceutical Co., Ltd
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masar@topule.com China 8467 58
Aladdin Scientific

tp@aladdinsci.com United States 57505 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 5221 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139
orders@jknbiochem.com China 6198 58
BOC Sciences 1-631-485-4226; 16314854226
info@bocsci.com United States 12952 65

BMS813160 ?? ??:

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