ChemicalBook >?? ???? >BMS813160
BMS813160
|
|
BMS813160 ??
- ??
- 1.31±0.1 g/cm3(Predicted)
- ?? ??
- 4°C, protect from light
- ???
- DMSO:61.0(Max Conc. mg/mL);125.86(Max Conc. mM)
Ethanol:97.0(Max Conc. mg/mL);200.14(Max Conc. mM)
- ??? ??
- ??? ??
- ?? ?? (pKa)
- 15.46±0.60(Predicted)
- ??
- White to off-white
- InChIKey
- CMVHFGNTABZQJU-HCXYKTFWSA-N
- SMILES
- C(N[C@@H]1C[C@H](NC(C)(C)C)CC[C@@H]1N1CC[C@H](NC2N3N=C(C(C)(C)C)C=C3N=CN=2)C1=O)(=O)C
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
BMS813160 C??? ??, ??, ??
??
BMS 813160 is a dual antagonist of chemokine receptor 2 (CCR2) and CCR5 (IC50s = 6.2 and 3.6 nM, respectively, in radioligand binding assays). It inhibits chemotaxis induced by the CCR2 ligand MCP-1 in THP-1 cells the CCR5 ligand MIP-1β in isolated peripheral T cells with IC50 values of 0.8 and 1.1 nM, respectively. BMS 813160 inhibits peritoneal monocyte and macrophage infiltration in an hCCR-2 KI mouse model of thioglycolate-induced peritonitis, with 54% inhibition when administered at a dose of 50 mg/kg twice per day.BMS813160 ?? ?? ? ???
???
?? ??
BMS813160 ?? ??
???( 66)?? ??
??? | ?? | ??? | ?? | ?? ? | ?? |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 33024 | 60 |
TargetMol Chemicals Inc. | +17819995354 |
marketing@targetmol.com | United States | 32301 | 58 |
Shenzhen Shengda Pharma Limited | 755-85269922 +8613424394241 |
sales@shengdapharm.com | CHINA | 310 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | |
support@targetmol.com | United States | 38672 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
Aladdin Scientific | |
tp@aladdinsci.com | United States | 57505 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 |
orders@jknbiochem.com | China | 5221 | 58 |
Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 086-15871494362 13720134139 |
orders@jknbiochem.com | China | 6198 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 |
info@bocsci.com | United States | 12952 | 65 |