IRL-2500
IRL-2500 ??? ???
?? ??:
169545-27-1
???:
IRL-2500
???(??):
IRL-2500;L-Tryptophan, 3-[1,1'-biphenyl]-4-yl-N-(3,5-dimethylbenzoyl)-N-methyl-D-alanyl-;N-3-[1,1'-BIPHENYL]-4-YL-N-(3,5-DIMETHYLBENZOYL)-N-METHYL-D-ALANYL-L-TRYPTOPHAN;((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan;((R)-3-([1,1'-Biphenyl]-4-yl)-2-(N,3,5-trimethylbenzamido)propanoyl)-L-tryptophan
CBNumber:
CB2281962
???:
C36H35N3O4
??? ??:
573.68
MOL ??:
169545-27-1.mol
IRL-2500 ??
?? ?
893.7±65.0 °C(Predicted)
??
1.246±0.06 g/cm3(Predicted)
?? ??
Keep in dark place,Sealed in dry,Store in freezer, under -20°C
???
Soluble to 100 mM in 1eq. NaOH
??? ??
??
?? ?? (pKa)
3.34±0.10(Predicted)
??
White to light yellow
??
?? ? ?? ??
?? ? ???? ?? (GHS)
????(GHS):
?? ?:
Warning
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P- ??
H302 ??? ???
?? ?? ?? - ??
?? 4
??
P264, P270, P301+P312, P330, P501
H315 ??? ??? ???
????? ?? ?????
?? 2
??
P264, P280, P302+P352, P321,P332+P313, P362
H319 ?? ?? ??? ???
?? ? ?? ?? ??? ??
?? 2A
??
P264, P280, P305+P351+P338,P337+P313P
H335 ?? ???? ??? ? ??
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?? 3
??
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P305+P351+P338 ?? ??? ? ?? ?? ???? ????. ???? ?????? ?????. ?? ????.
IRL-2500 C??? ??, ??, ??
??
IRL 2500 is a potent endothelin ETB selective antagonist.
???? ??
Potent endothelin receptor antagonist; shows some selectivity for ET B receptors (IC 50 values are 1.3 and 94 nM for ET B and ET A receptors respectively). Inhibits ET B receptor-mediated blood pressure increase and renal vascular resistance in rats in vivo .
IRL-2500 ?? ?? ? ???
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?? ??
IRL-2500 ?? ??
???( 54)?? ??
China 41
Europe 1
Germany 3
United Kingdom 1
United States 7
USA 1
Global 54
