ChemicalBook >?? ???? >??? ??>??????? ? >??????? ? ? ???>8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione ??? ???

?? ??:: 666816-98-4

???:: 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione

???(??):: 8-Bromo-7-(2-butyn-1-yl)-3-methylxanthine;8-broMo-7-(but-2-yn-1-yl)-3-Methyl-1H-purine-2,6(3H,7H)-dione;8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;3-Methyl-7-(2-butyn-1-yl)-8-bromoxanthine 8-Bromo-7-(2-butynyl)-3,7-dihydro-3-methyl-1H-purine-2,6-dione;Linagliptin INT1;8-BROMO-7-(BUT-2-YNYL);Linagliptin Impurity 36;Linagliptin Impurity 73;Iinagliptin Intermediate2;Linagliptin interMediateC

CBNumber:: CB22538943

???:: C10H9BrN4O2

??? ??:: 297.11

MOL ??:: 666816-98-4.mol

?? ?? 427

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione ??

???: 285 °C

??: 1.71

?? ??: 2-8°C

???: DMSO(?? ???), ???(?? ???)

??? ??: powder to crystal

?? ?? (pKa): 8.91±0.70(Predicted)

??: ???? ?? ??

LogP: 1.25 at 20℃

CAS ??????: 666816-98-4

?? ? ?? ??
?? ? ???? ?? (GHS)

HS ??	2933.99.8290

????(GHS):

?? ?:

??·?? ??:

??	??·?? ??	?? ??	??	?? ?	?? ??	P- ??
H412	??? ??? ?? ????? ???	?? ????? ?? - ??	?? 3			P273, P501

??????:

P273	???? ???? ???.
P501	...? ??? / ??? ?? ???.

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione C??? ??, ??, ??

??? ??

White powder

Synthesis

8-bromo-3-methyl-3,7-dihydro-1H-purine-2,6-dione (2.450 g, 10 mmol),1-bromo-2-butyne (1.596 g, 12 mmol), Sodium carbonate (1.590 g, 15 mmol), and 20mL of acetone was added to a 100mL flask. The reaction system was heated to 40 ° C, and the reaction was stirred for 4h. After the reaction was cooled to room temperature, suction filtration was performed, and the filter cake was washed with methanol to obtain a crude product as a pale yellow solid. The crude product was reconstituted with dichloromethane and cyclohexane. Yield 2.912 g of 8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione. The yield was 98%, and the purity was 99.9%.

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione ?? ?? ? ???

???

8-???-3-??-??? 1-BROMO-2-BUTYNE

?? ??

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione ?? ??

???( 427)?? ??

???	??	???	??	?? ?	??
Shanghai Joiny Pharmaceutical Co.,LTD	+86-13681955282 +86-13681955282	gyd@joiny-pharma.com	China	264	58
Sinoway Industrial co., ltd.	0592-5800732; +8613806035118	xie@china-sinoway.com	China	988	58
Anhui Ruihan Technology Co., Ltd	+8617756083858	daisy@anhuiruihan.com	China	973	58
Frapp's ChemicalNFTZ Co., Ltd.	+86 (576) 8169-6106	sales@frappschem.com	China	880	50
Capot Chemical Co.,Ltd.	+8613336195806	sales@capot.com	China	29731	60
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21622	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Anqing Chico Pharmaceutical Co., Ltd.	15380796838	chloewu@chicopharm.cn	CHINA	340	58

8-bromo-7-(but-2-ynyl)-3-methyl-1H-purine-2,6(3H,7H)-dione ?? ??:

Linagliptin impurity 15 (1R trans)-2-(3,4-difluorophenyl)cyclopropane amine Tetrahydro-2,2-dimethyl-4,7-methano-6H-1,3-dioxolo[4,5-d][1,2]oxazine-6-carboxylic acid phenylmethyl ester Canagliflozin Cyclopropanamine,2-(3,4-difluorophenyl)-(1R,2S) -(2R,3R)-2,3-dihydroxybutanedioate (1:1) Rivaroxaban 3-(R)-Piperidinyl PhthaliMide D-(-)-tartaric acid Linagliptin 5-Acetyl Rhein 1,1'-[(5E)-5-Methyl-7-oxo-5-undecene-1,11-diyl] Bis trans 1-Benzyl-4-(4-fluorophenyl)-3-piperidinemethanol Palonosetron Impurity 11 Clavulanate Potassium Impurity 12 DiHCl(Clavulanate Potassium EP Impurity M DiHCl) ZMZPVNYRPCNJGC-UHFFFAOYSA-N Pitavastatin Defuoro IMpurity CalciuM Salt 9-Piperazino Ofloxacin Chlorhexidine Diacetate Donepezil

午夜插插,噜噜噜影院,啪啪伊人网,欧美熟夫,景甜吻戏视频,男人强操性感蕾丝美女视频在线网站,日本美女跳舞视频