ChemicalBook >?? ???? >GM 1489
GM 1489
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GM 1489 ??
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- 795.4±60.0 °C(Predicted)
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- 1.203±0.06 g/cm3(Predicted)
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- Store at -20°C
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- DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 20 mg/ml; PBS (pH 7.2): 0.2 mg/ml
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- ?? ?? (pKa)
- 4.71±0.10(Predicted)
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GM 1489 C??? ??, ??, ??
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GM 1489 is a broad-spectrum inhibitor of matrix metalloproteinases (MMPs) with Ki values of 0.002, 0.1, 0.5, 0.2, and 20 μM for MMP-1, MMP-8, MMP-2, MMP-9, and MMP-3, respectively. It reduces 5-aza-2''-deoxycytidine-induced increases in MMP-1, MMP-2, MMP-3, MMP-7, MMP-9, and MMP-14 expression as well as cell invasion in AsPC-1, BxPC-3, Hs766T, MiaPaCa2, and PANC-1 cancer cells. Topical administration of GM 1489 (100 μg) inhibits increases in ear thickness and epidermal hyperplasia induced by phorbol 12-myristate 13-acetate (TPA; ) and phorbol dibutyrate (PdiBu) in mice.GM 1489 ?? ?? ? ???
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GM 1489 ?? ??
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| ??? | ?? | ??? | ?? | ?? ? | ?? |
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| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32159 | 58 |
| BOC Sciences | 16314854226 |
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| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 |
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| TargetMol Chemicals Inc. | 4008200310 |
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| Shanghai Yiyan Biotechnology Co. , Ltd. | 021-69985186 13611928337 |
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| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 |
sales@tybiochem.com | China | 6866 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 |
customer_service@efebio.com | China | 11974 | 58 |