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??????A
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??????A ??
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- 173-174 °C
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- 450.7±45.0 °C(Predicted)
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- 1.27±0.1 g/cm3(Predicted)
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- 2-8°C
- ???
- DMF: soluble; DMSO: soluble; Ethanol: soluble; Methanol: soluble
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- ?? ?? (pKa)
- 9.75±0.50(Predicted)
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Collismycin is a rare and unusual antibiotic belonging to the caerulomycin class, containing a core 2,2’-bispyridyl with an oxime substituent, produced by a strain of Streptomyces and discovered by researchers from Kirin, Japan in 1994. Collismycin was discovered as a potent inhibitor of glucocorticoid receptor binding. Collismycin has weak to moderate activity against bacteria, fungi and tumor cell lines. More recently, collismycin has been found to be a potent and selective neuroprotective agent against oxidative stress. Other recent publications have focused on the biosynthesis of collismycin as a route to the production of related analogues.??????A ?? ?? ? ???
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