ChemicalBook >?? ???? >1-??-4-??-????-3-????
1-??-4-??-????-3-????
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1-Benzyl-4-methyl-piperidin-3-one hydrochloride was used for the preparation of key intermediates of tofacitinib. Protein IR89 was utilized to catalyze the generation of (3R, 4R)-1-benzyl-N, 4-dimethylpiperidin-3-amine dihydrochloride from 1-benzyl-4-methylpiperidin-3-one or its hydrochloride and methylamine or its hydrochloride.1-??-4-??-????-3-???? ?? ?? ? ???
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1-??-4-??-????-3-???? ?? ??:
Tofacitinib Impurity 19
Tofacitinib impurity T
Methyl (4-Methylpiperidin-3-yl)carbaMate
4-CHLORO-7-TOSYL-7H-PYRROLO[2,3-D]PYRIMIDINE
BENZYL ETHYL ETHER
4-chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
N-methyl-N-((3R,4R)-4-methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine
Tofacitinib Impurity 85
N-((3R,4S)-1-benzyl-4-methylpiperidin-3-yl)-N-methyl-7H-pyrrolo[2,3-d]pyrimidin-4-amine
4-Amino-2,6-dichloropyrimidine
Malonyl chloride
Benzyl chloride
6-AMINO-5(2,2-DIETHOXYETHYL)-4-HYDROXY-2-MERCAPTOPYRIMIDINE
CYANOACETIC ACID-OSU
N-Hydroxysuccinimide
Tofacitinib Impurity 29
N-Methyl-N-((3S,4S)-4-Methylpiperidin-3-yl)-7H-pyrrolo[2,3-d]pyriMidin-4-aMine
(3S,4S)-Tofacitinib