ChemicalBook >?? ???? >4-???-7-??????-6-??????
4-???-7-??????-6-??????
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4-???-7-??????-6-?????? ??
- ???
- >205°C (dec.)
- ?? ?
- 426.7±45.0 °C(Predicted)
- ??
- 1.380±0.06 g/cm3(Predicted)
- ?? ??
- under inert gas (nitrogen or Argon) at 2-8°C
- ???
- DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- 15.28±0.30(Predicted)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?? ?????
- InChI
- InChI=1S/C11H9ClN2O2/c1-16-10-5-9-6(4-7(10)11(13)15)8(12)2-3-14-9/h2-5H,1H3,(H2,13,15)
- InChIKey
- ZBTVNIDMGKZSGC-UHFFFAOYSA-N
- SMILES
- N1C2C(=CC(C(N)=O)=C(OC)C=2)C(Cl)=CC=1
- CAS ??????
- 417721-36-9
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| HS ?? | 2933499090 |
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| ????(GHS): |
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4-???-7-??????-6-?????? C??? ??, ??, ??
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4-chloro-7-Methoxyquinoline-6-carboxaMide is a pharmaceutical intermediate compound used in the preparation of Lenvatinib, an oral multi-receptor tyrosine kinase inhibitor approved by the FDA for the treatment of radioiodine-refractory differentiated thyroid cancer (DTC), unresectable (DTC), unresectable hepatocellular carcinoma (HCC), and advanced renal cell carcinoma (RCC).??
Pharmaceutical Intermediates. 4-chloro-7-Methoxyquinoline-6-carboxaMide is used as an intermediate for synthesizing Lenvatinibis.4-???-7-??????-6-?????? ?? ?? ? ???
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4-???-7-??????-6-?????? ?? ??
???( 372)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| SyncoZymes (Shanghai) Co., Ltd., | +8613681683526 |
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sales@ichemie.com | China | 1015 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8615965530500 |
nickzhang@hangyubiotech.com | China | 10989 | 58 |
| Capot Chemical Co.,Ltd. | +8613336195806 |
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| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 |
info@dakenam.com | China | 19837 | 58 |
4-???-7-??????-6-?????? ?? ??:
?????
7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxaMide
1-(2-chloro-4-hydroxyphenyl)-3-cyclopropylurea
7-methoxy-4-chloro-quinoline-6-carbonyl chloride
Clioquinol
Lansoprazole
L-Glutamine, phenylmethyl ester
2-AMINOMETHYLPYRIMIDINE HYDROCHLORIDE
synthesis-020
synthesis-022
Lenvatinib Impurity d
Lenvatinib Impurity 12
Lenvatinib Impurity g
4-Amino-3-chlorophenol hydrochloride
lenvatinib Mesylate
Methyl 7-Methoxy-4-oxo-1,4-dihydroquinoline-6-carboxylate
Methyl 4-chloro-7-Methoxyquinoline-6-carboxylate
4-Amino-3-chlorophenol