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Indications

Iodophors (Acu-Dyne, Aerodine, Betadine, Iodex, Operand, Polydine). These consist of a water-soluble organic complex of iodine with a carrier that slowly liberates iodine on contact with reducing substances in body tissues. These broad-range germicidal antiseptics are effective against bacteria, fungi, viruses, protozoa, and yeast. They are water soluble, nonirritating, and nonstinging but may lose effectiveness on contact with whole blood or serum. They are often used for preoperative skin cleansing and surgical scrubbing because their sustained action provides protection even through lengthy procedures.
They are also used in treating skin infections and burns. They are available in many vehicles. The solubilizing carrier substances include polyvinyl–pyrrolidone (povidone-iodine, as in Betadine products or available as generics) and poloxamer–iodine complexes. Because iodophors may be absorbed through the skin, they should be avoided in neonates or in patients with thyroid disorders. Also, extensive use for prolonged periods should be minimized. Iodine preparations may slow wound healing on actively granulating tissue.

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