5-???????
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5-??????? ??
- ???
- 121-123 °C (lit.)
- ?? ?
- 325.75°C (rough estimate)
- ??
- 1.0815 (rough estimate)
- ???
- 1.5700 (estimate)
- ?? ??
- 2-8°C
- ???
- ?????(?? ???), ???(?? ???)
- ??? ??
- ?? ??
- ?? ?? (pKa)
- 16.91±0.30(Predicted)
- ??
- ???
- Merck
- 13,6032
- BRN
- 145587
- InChI
- InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
- InChIKey
- JTEJPPKMYBDEMY-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=C(OC)C=C2)C(CCN)=C1
- CAS ??????
- 608-07-1(CAS DataBase Reference)
??
- ?? ? ?? ??
- ?? ? ???? ?? (GHS)
| ??? ?? | Xn | ||
|---|---|---|---|
| ?? ???? ?? | 22-36/37/38-20/21/22 | ||
| ????? | 36-26 | ||
| WGK ?? | 3 | ||
| RTECS ?? | NL4110000 | ||
| F ?????? | 8 | ||
| HS ?? | 29339900 | ||
| ?? | LD50 intraperitoneal in mouse: 176mg/kg |
5-??????? C??? ??, ??, ??
??
5-Methoxytryptamine (5-MT), also known as mexamine, is a tryptamine derivative closely related to the neurotransmitters serotonin and melatonin. 5-MT has been shown to occur naturally in the body in low levels.It is biosynthesized via the deacetylation of melatonin in the pineal gland.The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.
Melatonin and its metabolites ameliorate ultraviolet B-induced damage in human epidermal keratinocytes.
??? ??
White to tan crystalline powder??
5-Methoxytryptamine (Mexamine, Methoxytryptamine) is a tryptamine derivative that is closely related to the neurotransmitter Melatonin (M215000) and Serotonin (S274980). It acts as a full agonist at the 5-HT1, 5-HT2, 5-HT4, 5-HT6, and 5-HT7 receptors but has no affinity for the 5-HT3 receptor.?? ??
5-Methoxytryptamine was used as an agonist in the study of pharmacological profile of the 5-hydroxytryptamine 1 receptor.Reactant for preparation of:
Carboline disaccharide domain of shishijimicin A
Melatonin analogs for the reduction of intraocular pressure
5-HT4 receptor ligands
inhibitors of sortase A and isocitrate lyase
Therapeutic agents for treatment of ischemia/reperfusion (I/R) injury
Aurora and epidermal growth factor receptor kinase inhibitors
Agents for the treatment of human papillomavirus infection
Manzamine analogues for the control of neuroinflammation and cerebral infections
Inhibitors of pro-inflammatory cytokines
Tacrine-melatonin hybrids as multifunctional agents for alzheimer′s disease
??
ChEBI: 5-methoxytryptamine is a member of the class of tryptamines that is the methyl ether derivative of serotonin. It has a role as a serotonergic agonist, a human metabolite, a mouse metabolite, a 5-hydroxytryptamine 2A receptor agonist, a 5-hydroxytryptamine 2C receptor agonist, a 5-hydroxytryptamine 2B receptor agonist, an antioxidant, a radiation protective agent, a neuroprotective agent and a cardioprotective agent. It is a member of tryptamines, an aromatic ether and a primary amino compound. It derives from a serotonin. It is a conjugate base of a 5-methoxytryptamine(1+).?? ??
The protective effect of 5-methoxytryptamine (a metabolite of melatonin) in human keratinocytes against ultraviolet B (UVB) radiation was studied.5-??????? ?? ?? ? ???
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5-??????? ?? ??
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5-??????? ?? ??:
P-???? ??????????? ??? ??????? ?????????? ?? ??
4-Methoxyphenylacetone
Serotonin hydrochloride
3-(METHOXYMETHOXY)BENZALDEHYDE
Melatonine
Methoxyammonium chloride
5-Methoxytryptamine hydrochloride
2-PHENYLMELATONIN
N-Acetyl-2-iodo-5-methoxytryptamine
6-METHOXY-1,2,3,4-TETRAHYDRO-BETA-CARBOLINE
2-(5-BENZYLOXY-1H-INDOL-3-YL)-ETHYLAMINE
IBOGAINE HYDROCHLORIDE--DEA*SCHEDULE I I TEM
6-METHOXYTRYPTAMINE