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?? ???? >2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
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2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide ??? ???
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- ?? ??:
- 1307896-46-3
- ???:
- 2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide
- ???(??):
- RMM 46;RMM 46,RMM46;2-Cyano-N-(1-hydroxy-2-methylpropan-2-yl)-3-(3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl)acrylamide;2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide;2-Propenamide, 2-cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-
- CBNumber:
- CB04902742
- ???:
- C24H26N4O5
- ??? ??:
- 450.49
- MOL ??:
- 1307896-46-3.mol
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2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide ??
- ?? ?
- 725.5±60.0 °C(Predicted)
- ??
- 1.277±0.06 g/cm3(Predicted)
- ?? ??
- Store at -20°C
- ???
- DMSO? ???
- ??? ??
- ??
- ?? ?? (pKa)
- 11.04±0.46(Predicted)
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2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide C??? ??, ??, ??
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RMM 46 is a reversible covalent inhibitor that exhibits high ligand efficiency and selectivity for MSK/RSK-family kinases.
2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide ?? ?? ? ???
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2-Cyano-N-(2-hydroxy-1,1-dimethylethyl)-3-[3-(3,4,5-trimethoxyphenyl)-1H-indazol-5-yl]-2-propenamide ?? ??
???( 15)?? ??
