Maltol acetate synthesis
- Product Name:Maltol acetate
- CAS Number:28787-36-2
- Molecular formula:C8H8O4
- Molecular Weight:168.15
Yield:28787-36-2 98%
Reaction Conditions:
at 90; for 6 h;
Steps:
2.2. Synthesis of DDMP from maltol
Maltol (10 g, 80 mmol) was dissolved in acetic anhydride (15 mL), the mixture was heated at 90 C for 6 h, then cooled and ethyl acetate (200 mL) was added. The ethyl acetate solution was washed with saturated aqueous NaHCO3 (1 × 100 mL), then aqueous NaCl (2 × 200 mL), dried over anhydrous Na2SO4 then evaporated under reduced pressure to give 2 as a yellow oil 13.2 g, yield 98%. 1H NMR (600 MHz, CDCl3) δ 7.69 (d, J = 5.7 Hz, 1H, H-2), 6.40 (d, J = 5.7 Hz, 1H, H-3), 2.34 (s, 3H, -OCH3), 2.27 (s, 3H, H-7). 13C NMR (150 MHz, CDCl3) δ 172.0 (C- 4), 167.6 (-O-C- - O), 159.1 (C-2), 154.3 (C-6), 138.7(C-5), 116.8 (C-3), 20.3 (-OCH3), 15.0 (C-7). HR-ESI-MS m/z calculated for C8H8O4 [M + H]+ 169.0495, found 169.0494.
References:
Chen, Zhifei;Xi, Gaolei;Fu, Yufeng;Wang, Qingfu;Cai, Lili;Zhao, Zhiwei;Liu, Qiang;Bai, Bing;Ma, Yuping [Food Chemistry,2021,vol. 361,art. no. 130052]
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