O-ACETYLSALICYLOYL CHLORIDE synthesis
- Product Name:O-ACETYLSALICYLOYL CHLORIDE
- CAS Number:5538-51-2
- Molecular formula:C9H7ClO3
- Molecular Weight:198.6
50-78-2
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5538-51-2
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Yield:5538-51-2 98.5%
Reaction Conditions:
with oxalyl dichloride;N,N-dimethyl-formamide in dichloromethane at 20; for 3 h;
Steps:
3.2.1. Synthesis of compound 1
To a solution of acetylsalicylic acid (5 g, 27.8 mmol) in 50 mL of anhydrous dichloromethane (DCM), 3.3 mL of oxalyl chloride and a drop of dimethylformamide were added slowly and the mixture was stirred for 3 h at room temperature. Then the mixture was concentrated and 5.4 g of compound 1 was obtained (yield: 98.5%).
References:
Chen, Zhimin;Luo, Yi;Fang, Aiping;Fan, Chen;Zeng, Chenjuan [Turkish Journal of Chemistry,2018,vol. 42,# 3,p. 929 - 939]
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50-78-2
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5538-51-2
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69-72-7
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5538-51-2
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5538-51-2
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5538-51-2
191 suppliers
$30.00/1 g