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N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩

N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩 化學(xué)構(gòu)造式
334-50-9
CAS番號(hào).
334-50-9
化學(xué)名:
N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩
別名:
スペルミジン3塩酸塩;スペルミジン·3塩酸塩;N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩;スペルミジン三塩酸塩;スペルミジン, 三塩酸塩, 結(jié)晶;スペルミジン 三塩酸塩;スペルミジン, 三塩酸塩, 結(jié)晶, 99%
英語(yǔ)名:
Spermidine trihydrochloride
英語(yǔ)別名:
SPERMIDINE HCl;Spermidie 3HCL;SPERMIDINE HYDROCHLORIDE;SperMidine tri;SPERMIDINE 3HC;SPERMIDINE 3HCL;Spermidine 3HCl>98%;Spermidine·3hydrochloride;SPERMIDINE TRIHYDROCHLORIDE;SPERMIDINE.3HCLRESEARCH GRADE
CBNumber:
CB7223105
化學(xué)式:
C7H22Cl3N3
分子量:
254.63
MOL File:
334-50-9.mol
MSDS File:
SDS

N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩 物理性質(zhì)

融點(diǎn) :
257-259 °C(lit.)
貯蔵溫度 :
room temp
溶解性:
H2O: 1M at20℃、透明、無(wú)色
外見(jiàn) :
結(jié)晶性粉末
色:
白い
PH:
3.0-6.0 (25℃, 1M in H2O)
由來(lái)生物:
microbial
synthetic
水溶解度 :
水に溶ける
極大吸収波長(zhǎng) (λmax):
λ: 260 nm Amax: 0.2
λ: 280 nm Amax: 0.1
BRN :
3552356
InChI:
InChI=1S/C7H19N3.3ClH/c8-4-1-2-6-10-7-3-5-9;;;/h10H,1-9H2;3*1H
InChIKey:
LCNBIHVSOPXFMR-UHFFFAOYSA-N
SMILES:
C(CCCN)NCCCN.Cl.Cl.Cl
CAS データベース:
334-50-9(CAS DataBase Reference)
EPAの化學(xué)物質(zhì)情報(bào):
1,4-Butanediamine, N-(3-aminopropyl)-, trihydrochloride (334-50-9)
安全性情報(bào)
  • リスクと安全性に関する聲明
  • 危険有害性情報(bào)のコード(GHS)
主な危険性  Xi
Rフレーズ  36/37/38
Sフレーズ  26-36
WGK Germany  3
RTECS 番號(hào) EJ7023000
3-10
TSCA  Yes
HSコード  29212900
絵表示(GHS) GHS hazard pictograms
注意喚起語(yǔ) 警告
危険有害性情報(bào)
コード 危険有害性情報(bào) 危険有害性クラス 區(qū)分 注意喚起語(yǔ) シンボル P コード
H315 皮膚刺激 皮膚腐食性/刺激性 2 警告 GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 強(qiáng)い眼刺激 眼に対する重篤な損傷性/眼刺激 性 2A 警告 GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
注意書(shū)き
P264 取扱い後は皮膚をよく洗うこと。
P264 取扱い後は手や顔をよく洗うこと。
P280 保護(hù)手袋/保護(hù)衣/保護(hù)眼鏡/保護(hù)面を著用するこ と。
P302+P352 皮膚に付著した場(chǎng)合:多量の水と石鹸で洗うこと。
P305+P351+P338 眼に入った場(chǎng)合:水で數(shù)分間注意深く洗うこと。次にコ ンタクトレンズを著用していて容易に外せる場(chǎng)合は外す こと。その後も洗浄を続けること。
P332+P313 皮膚刺激が生じた場(chǎng)合:醫(yī)師の診斷/手當(dāng)てを受けるこ と。
P337+P313 眼の刺激が続く場(chǎng)合:醫(yī)師の診斷/手當(dāng)てを受けること。

N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩 価格 もっと(18)

メーカー 製品番號(hào) 製品説明 CAS番號(hào) 包裝 価格 更新時(shí)間 購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako) W01COBQC-3353 スペルミジン三塩酸塩
Spermidine trihydrochloride
334-50-9 1g ¥18000 2024-03-01 購(gòu)入
富士フイルム和光純薬株式會(huì)社(wako) W01COBQC-3353 スペルミジン三塩酸塩
Spermidine trihydrochloride
334-50-9 5g ¥49500 2024-03-01 購(gòu)入
関東化學(xué)株式會(huì)社(KANTO) 21510-1A スペルミジン三塩酸塩 >99.0%
Spermidine trihydrochloride >99.0%
334-50-9 5g ¥20570 2024-07-01 購(gòu)入
Sigma-Aldrich Japan 85578 スペルミジン 三塩酸塩 BioXtra, ≥99.5% (AT)
Spermidine trihydrochloride BioXtra, ≥99.5% (AT)
334-50-9 1g ¥7780 2024-03-01 購(gòu)入
Sigma-Aldrich Japan 85578 スペルミジン 三塩酸塩 BioXtra, ≥99.5% (AT)
Spermidine trihydrochloride BioXtra, ≥99.5% (AT)
334-50-9 5g ¥28700 2024-03-01 購(gòu)入

N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩 化學(xué)特性,用途語(yǔ),生産方法

説明

Spermidine trihydrochloride is a polyamine that inhibits neuronal nitric oxide synthase (nNOS) and binds and precipitates DNA. It may be used to purify DNA binding proteins. Additionally, spermidine stimulates T4 polynucleotide kinase activity. It is involved in growth, development, and the stress response in plants.

化學(xué)的特性

Spermidine trihydrochloride appears as white to off-white crystalline powder, which is soluble in water(100mg/ml-clear, colorless solution), very hygroscopic, and air-sensitive.

化學(xué)反応性

Spermidine hydrochloride is a white crystal at normal temperature and pressure. It is the hydrochloride form of spermidine.When it is used, it is often reacted with alkali to release a triamine structure.

使用

Spermidine Trihydrochloride is a NOS1 inhibitor and NMDA and T4 activator. Polyamine that plays an important role in the regulation of cellular proliferation and differentiation. It was in a structural and functional study of polyamines, where potassium and sodium ions were found to promote different effects when binding with polyamines. Spermidine trihydrochloride has been used in fourier transform infrared spectroscopy (FTIR)characterization and in zeta-potential measurements.

利點(diǎn)

Spermidine trihydrochloride has been extensively studied for its potential health benefits, including its ability to modulate autophagy, enhance cardiovascular health, protect against neurodegenerative diseases, and exhibit antioxidant activity. Studies have shown that it can enhance cardiovascular health by promoting blood vessel relaxation, reducing oxidative stress, and improving mitochondrial function. It has also been suggested to have neuroprotective effects and may contribute to cognitive health and brain function. It has shown promising results in preclinical studies, demonstrating its ability to protect neurons, reduce inflammation, and enhance cellular resilience.

生物學(xué)の機(jī)能

Spermidine inhibits NOS1 (nNOS). Spermidine binds and precipitates DNA and may be used for purification of DNA binding proteins. Spermidine activates PNK (polynucleotide kinase T4). Spermidine binds to and activates NMDA and has been shown to potentiate NMDA-induced currents in a concentration-dependent manner.

一般的な説明

Spermidine trihydrochloride is the hydrochloric acid neutralized salt of spermidine. Spermidine is a polyamine and a trivalent organic cation. It is a natural polyamine that stimulates cytoprotective macroautophagy/autophagy. External supplementation of spermidine extends lifespan and health span across species, including in yeast, nematodes, flies and mice. Spermidine trihydrochloride is a more stable form because spermidine is very air sensitive.

生物活性

Binds to the polyamine modulatory site of the NMDA receptor and has been described as an agonist based on its ability to enhance the binding of [ 3 H]-MK801.
Spermidine trihydrochloride is an aliphatic polyamine. Its crystalline structure has been studied. It has been reported to preserve the nuclei and prevent proteolytic degradation of histones during the macronuclei isolation from Tetrahymena pyriformis.

純化方法

Recrystallise the salt from dry 3% HCl in ethanol and adding dry Et2O if necessary. Filter it off rapidly and dry it in a vacuum desiccator. Alternatively centrifuge the crystals off, wash them with dry Et2O and dry them in a vacuum. [Beilstein 4 IV 1300.]

N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩 上流と下流の製品情報(bào)

原材料

準(zhǔn)備製品


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N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩  スペクトルデータ(FT-IR、IR、Raman)


334-50-9(N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩)キーワード:


  • 334-50-9
  • 4-butanediamine,n-(3-aminopropyl)-trihydrochloride
  • 4-azoniaoctamethylenediammonium trichloride
  • 1,8-DIAMINO-4-AZAOCTANE TRIHYDROCHLORIDE
  • SPERMIDINE TRIHYDROCHLORIDE N-(3-AMINOPR OPYL)-1,4
  • Spermidine trihydrochloride, 99+%
  • Spermidine·3hydrochloride
  • SPERMIDINE 3HC
  • SPERMIDINE.3HCLRESEARCH GRADE
  • SPERMIDINE *3HClMOLECULAR BIOLOGY GRADE
  • Spermidine trihydrochloride,N-(3-Aminopropyl)-1,4-butanediamine trihydrochloride
  • SperMidine trihydrochloride, 99+% 5GR
  • N1-(3-AMinopropyl)butane-1,4-diaMine trihydrochloride
  • N-(3-aMinopropyl)butane-1,4-diaMinetrihydrochloride
  • SperMidine tri
  • SPERMIDINE TRIHYDROCHLORIDE BIOXTRA
  • N-[3-AMINOPROPYL]-1,4-BUTANEDIAMINE 3 H CL
  • N-(3-AMINOPROPYL)-1 4-BUTANEDIAMINE HYDROCHLORIDE
  • N-(3-AMINOPROPYL)-1,4-BUTANEDIAMINE TRIHYDROCHLORIDE
  • N-(3-AMINOPROPYL)-1,4-DIAMINOBUTANE 3HCL
  • N-(3-AMINOPROPYL)-1,4-DIAMINO-BUTANE TRIHYDROCHLORIDE
  • SPERMIDINE 3HCL
  • SPERMIDINE TRIHYDROCHLORIDE
  • 1,4-Butanediamine,N-(3-aminopropyl)-,trihydrochloride
  • Spermidine, Trihydrochloride - CAS 334-50-9 - Calbiochem
  • Spermidine trihydrochloride, ≥98(TLC)
  • 4-Azaoctamethylenediamine trihydrochloride
  • SPERMIDINE TRIHYDROCHLORIDE ISO 9001:2015 REACH
  • Spermidine trihydrochloride 98%
  • Spermidine trihydrochloride 5%
  • SPERMIDINE HCl
  • スペルミジン3塩酸塩
  • スペルミジン·3塩酸塩
  • N-(3-アミノプロピル)-1,4-ブタンジアミン·3塩酸塩
  • スペルミジン三塩酸塩
  • スペルミジン, 三塩酸塩, 結(jié)晶
  • スペルミジン 三塩酸塩
  • スペルミジン, 三塩酸塩, 結(jié)晶, 99%
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