ent-LP 99
- CAS No.
- 1808948-28-8
- Chemical Name:
- ent-LP 99
- Synonyms
- 3R)-LP99;ent-LP 99;(2S,3R)-LP99;1-Propanesulfonamide, N-[(2S,3R)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-
- CBNumber:
- CB98202858
- Molecular Formula:
- C26H30ClN3O4S
- Molecular Weight:
- 516.05
- MDL Number:
- MOL File:
- 1808948-28-8.mol
ent-LP 99 Chemical Properties,Uses,Production
Uses
(2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1].
IC 50
BRD7; BRD9: 99 nM (Kd)
storage
Store at -20°C
References
[1] Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21. DOI:10.1002/anie.201501394
ent-LP 99 Preparation Products And Raw materials
Raw materials
Preparation Products
ent-LP 99 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32286 | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| TargetMol Chemicals Inc. | 15002134094 | marketing@targetmol.cn | China | 21356 | 58 |
| R&D Systems, Inc | 18003437475 18003437475 | rdname@qq.com | China | 6960 | 58 |
| Supplier | Advantage |
|---|---|
| TargetMol Chemicals Inc. | 58 |
| Shanghai Hongye Biotechnology Co. Ltd | 58 |
| TargetMol Chemicals Inc. | 58 |
| R&D Systems, Inc | 58 |