| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
|
| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:ent-LP 99
CAS:1808948-28-8
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:(2S,3R)-LP99
CAS:1808948-28-8
Package:5mg/RMB 11450
|
| Company Name: |
R&D Systems, Inc
|
| Tel: |
18003437475 18003437475 |
| Email: |
rdname@qq.com |
| Products Intro: |
Product Name:ent-LP 99
CAS:1808948-28-8
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|
| | ent-LP 99 Basic information |
| Product Name: | ent-LP 99 | | Synonyms: | ent-LP 99;(2S,3R)-LP99;3R)-LP99;1-Propanesulfonamide, N-[(2S,3R)-2-(4-chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl- | | CAS: | 1808948-28-8 | | MF: | C26H30ClN3O4S | | MW: | 516.05 | | EINECS: | | | Product Categories: | | | Mol File: | 1808948-28-8.mol |  |
| | ent-LP 99 Chemical Properties |
| Boiling point | 726.6±70.0 °C(Predicted) | | density | 1.36±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 9.56±0.40(Predicted) |
| | ent-LP 99 Usage And Synthesis |
| Uses | (2S,3R)-LP99 is a potent and selective BRD7 and BRD9 inhibitor with an KD of 99 nM for BRD9. (2S,3R)-LP99 inhibits the association of BRD7 and BRD9 to acetylated histones in vitro and in cells. (2S,3R)-LP99 demonstrates that BRD7/9 plays a role in regulating pro-inflammatory cytokine secretion[1]. | | IC 50 | BRD7; BRD9: 99 nM (Kd) | | storage | Store at -20°C | | References | [1] Clark PG, et al. LP99: Discovery and Synthesis of the First Selective BRD7/9 Bromodomain Inhibitor. Angew Chem Int Ed Engl. 2015 May 18;54(21):6217-21. DOI:10.1002/anie.201501394 |
| | ent-LP 99 Preparation Products And Raw materials |
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