ChemicalBook >> CAS DataBase List >>Pilsicainide hydrochloride
Pilsicainide hydrochloride
- CAS No.
- 88069-49-2
- Chemical Name:
- Pilsicainide hydrochloride
- Synonyms
- Pilsinic;Rizumcote;Alisrythm;Tatsupilljin;PILSICAININIDE;Pilsicainide hydrochoride;Pilsicainide-Hydrochlordie;Pilzicainide hydrochloride;PILSICAINIDE HYDROCHLORIDE;Pilsicainide HCl, 10 mM in DMSO
- CBNumber:
- CB9699294
- Molecular Formula:
- C17H24N2O
- Molecular Weight:
- 272.39
- MDL Number:
- MFCD00903769
- MOL File:
- 88069-49-2.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
| Melting point | 212-214° |
|---|---|
| storage temp. | room temp |
| solubility | Chloroform (Slightly), Water (Slightly) |
| form | powder |
| color | white to beige |
| Water Solubility | deionized water: >5mg/mL |
| FDA UNII | 03C8I9296V |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Symbol(GHS) | GHS06 |
|||||||||
| Signal word | Danger | |||||||||
| Signal word | Danger | |||||||||
| Hazard statements | H301 | |||||||||
| Hazard statements | H301 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| Precautionary statements | P264-P270-P301+P310-P405-P501 | |||||||||
| RIDADR | UN 2811 6.1 / PGIII | |||||||||
| WGK Germany | 3 | |||||||||
| HS Code | 2933.99.7000 | |||||||||
| Toxicity | LD50 in mice (mg/kg): 410 s.c. (Miyano, 1985) | |||||||||
| NFPA 704 |
|
Pilsicainide hydrochloride price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P0026 | Pilsicainide hydrochloride ≥98% (HPLC) | 88069-49-2 | 10MG | $97.5 | 2023-06-20 | Buy |
| Sigma-Aldrich | P0026 | Pilsicainide hydrochloride ≥98% (HPLC) | 88069-49-2 | 50MG | $382 | 2023-06-20 | Buy |
| TCI Chemical | P2634 | Pilsicainide Hydrochloride | 88069-49-2 | 50MG | $154 | 2024-03-01 | Buy |
| TCI Chemical | P2634 | Pilsicainide Hydrochloride | 88069-49-2 | 250MG | $456 | 2024-03-01 | Buy |
| TRC | P441508 | Pilsicainide Hydrochloride | 88069-49-2 | 10mg | $45 | 2021-12-16 | Buy |
Pilsicainide hydrochloride Chemical Properties,Uses,Production
Description
Pilsicainide hydrochloride is a new pynolizidine lidocaine derivative with antiarrhythmic activity. It is the first pharmaceutical product introduced by Suntory and was solely developed in Japan. The compound is reported to be highly effective in the treatment of premature ventricular contraction. It has no anticholinergic or CNS activity and is not as likely as other class 1C antiarrhythmics to have restricted indications.
Originator
Suntory (Japan)
Uses
Pilsicainide hydrochloride has been used as a sodium channel blocker:
- to study its effects on electrophysiological parameters in guinea pig pulmonary vein preparation
- to study its effects on Ca2+?release and arrhythmic events in Andersen-Tawil syndrome induced pluripotent stem cells (ATS-iPSC)-derived cardiomyocytes
- to study its electrophysiological effects on the guinea pig atrium
brand name
Sunrhythm
Biochem/physiol Actions
Pilsicainide hydrochloride is a pure sodium channel blocker and an open channel blocker of Na+1 channels. Pilsicainide was defined as a pure sodium channel blocker. The compound is classified as a class Ic antiarrhythmic drug, and was originally developed in Japan. Similar to Lidocaine, Pilsicainide binds to open channels, but slowly. Pilsicainide is capable of selectively blocking the late currents in the mutant Na(+) channels that show dominant abnormal burst openings such as in δKPQ mutants. The compound is used to induce Brugada syndrome (BS) in animal models.
Pilsicainide hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 112)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Capot Chemical Co.,Ltd. | +86-（0）57185586718 +86-13336195806 | sales@capot.com | China | 29793 | 60 |
| Beijing Cooperate Pharmaceutical Co.,Ltd | 010-60279497 | sales01@cooperate-pharm.com | CHINA | 1803 | 55 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21634 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29879 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 | sales@chemdad.com | China | 39894 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49374 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569262 +86-15003564040 | 1087@dideu.com | China | 3167 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17365 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-89586680 +86-18192503167 | 1026@dideu.com | China | 7724 | 58 |
View Lastest Price from Pilsicainide hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-01-03 | Pilsicainide hydrochloride
88069-49-2
|
US $1.00-1.00 / KG | 1g | 99% | 50tons | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-11-20 | Pilsicainide HCl
88069-49-2
|
US $64.00-89.00 / mg | 99.96% | 10g | TargetMol Chemicals Inc. | ||
 |
2019-07-06 | Pilsicainide hydrochloride
88069-49-2
|
US $1.00 / kg | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Pilsicainide hydrochloride
88069-49-2
- US $1.00-1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
-
- Pilsicainide HCl
88069-49-2
- US $64.00-89.00 / mg
- 99.96%
- TargetMol Chemicals Inc.
-
- Pilsicainide hydrochloride
88069-49-2
- US $1.00 / kg
- 99%
- Career Henan Chemical Co
88069-49-2(Pilsicainide hydrochloride)Related Search:
Pilzicainide hydrochloride
Rizumcote
Tatsupilljin
Pilsicainide-Hydrochlordie
N-(2,6-Dimethylphenyl)-2-(hexahydro-1H-pyrrolizin-7a-yl)acetamide hydrochloride
n-(2,6-dimethylphenyl)-2-(1,2,3,5,6,7-hexahydropyrrolizin-8-yl)acetamide hydrochloride
PILSICAINIDE HYDROCHLORIDE
PILSICAINIDE HYDROCHLORIDE HEMIHYDRATE
PILSICAININIDE
Pilsicainide hydrochoride
PILSICAINIDEHYDROCHLORIDE(FORRESEARCHONLY)
Pilsicainide Hydrochloride and intermediates
Alisrythm
Pilsinic
Pilsicainide hydrochloride USP/EP/BP
C17H24N2O Pilsicainide hydrochloride 88069-49-2
atrial tachyarrhythmias,SUN-1165,Pilsicainide HCl,antiarrhythmic,inhibit,orally active,SUN1165,Inhibitor,Na+ channels,Na channels,Pilsicainide,Sodium Channel
Pilsicainide HCl, 10 mM in DMSO
88069-49-2
C17H24N2O
C17H24N2OHCl
C17H24N2OHCl12H2O
APIs