CHOLESTA-3,5-DIENE
- CAS No.
- 747-90-0
- Chemical Name:
- CHOLESTA-3,5-DIENE
- Synonyms
- Cholestadiene;CHOLESTERILENE;CHOLESTERYLENE;3,5-CHOLESTADIEN;3,5-CHOLESTADIENE;CHOLEST-3,5-DIENE;CHOLESTA-3,5-DIENE;Cholestane-3,5-diene;delta-3,5-Cholestadiene;delta(Sup3,5)-Cholestadiene
- CBNumber:
- CB9284144
- Molecular Formula:
- C27H44
- Molecular Weight:
- 368.64
- MDL Number:
- MFCD00009939
- MOL File:
- 747-90-0.mol
- MSDS File:
- SDS
| Melting point | 78-80 °C (lit.) |
|---|---|
| Boiling point | 433.93°C (rough estimate) |
| Density | 0.9250 |
| refractive index | 1.4922 (estimate) |
| storage temp. | -20°C |
| form | Solid |
| color | White to off-white |
| biological source | natural (organic) |
| EWG's Food Scores | 1 |
| UNSPSC Code | 12352211 |
| NACRES | NA.77 |
CHOLESTA-3,5-DIENE price More Price(8)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | C6012 | Cholesta-3,5-diene ≥93% (HPLC) | 747-90-0 | 25mg | $179 | 2024-03-01 | Buy |
| Sigma-Aldrich | C6012 | Cholesta-3,5-diene ≥93% (HPLC) | 747-90-0 | 100mg | $541 | 2024-03-01 | Buy |
| TRC | C431508 | Cholesta-3,5-diene | 747-90-0 | 50mg | $225 | 2021-12-16 | Buy |
| TRC | C431508 | Cholesta-3,5-diene | 747-90-0 | 10mg | $80 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | SHG0000261 | CHOLESTA-3,5-DIENE 95.00% | 747-90-0 | 25MG | $655.74 | 2021-12-16 | Buy |
CHOLESTA-3,5-DIENE Chemical Properties,Uses,Production
Uses
Cholesta-3,5-diene was used as standard in HPLC in quality analysis of different types of olive oils and edible fats.
Definition
ChEBI: Cholesta-3,5-diene is a cholestanoid.
Biochem/physiol Actions
Cholesta-3,5-diene is an oxysterol, a cholesterol derivative by auto-oxidation. Oxysterols are non-genomic regulators of cholesterol homeostasis. The biological effects include protein prenylation, apoptosis, modulation of sphingolipid metabolism and platelet aggregation. Oxysterols bind to liver X receptors, modulate cholesterol efflux and decrease the uptake of cholesterol by the cells.
in vivo
Neutrophil Recruitment: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) promotes neutrophil recruitment to tailfin wounds in transgenic zebrafish larvae (Tg(mpx:GFP)) by 6 h post-treatment1.
Tissue Regeneration: Cholesta-3,5-diene (30 μg/ml; topical application; single dose) does not enhance tissue regeneration in zebrafish tailfin wounds, unlike the lipid fraction Ft containing Cholesta-3,5-diene1.
| Animal Model: | Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)[1] |
| Dosage: | 30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium) |
| Administration: | Topical application to transected tailfin immediately after wounding, single dose |
| Result: | Significantly increased neutrophil accumulation at the wound site by 6 h post-treatment (2-fold vs. vehicle control. No effect was observed in uninjured tailfins[1]. |
| Animal Model: | Transgenic zebrafish larvae (Tg(mpx:GFP), 4 days post-fertilization, male/female mixed, 200-300 mg)1 |
| Dosage: | 30 μg/mL Cholesta-3,5-diene (dissolved in ethanol, diluted in E2 medium) |
| Administration: | Topical application to transected tailfin immediately after wounding, single dose |
| Result: | Did not promote significant tissue regeneration at 2 or 6 days post-treatment, unlike the lipid fraction Ft (which showed dose-dependent regeneration). Resulted maximum regeneration with Ft of 50 μg/mL. |
CHOLESTA-3,5-DIENE Preparation Products And Raw materials
Raw materials
Preparation Products
CHOLESTA-3,5-DIENE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Alfa Chemistry | Info@alfa-chemistry.com | United States | 24072 | 58 | |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53900 | 58 |
| Shanghai Aladdin Bio-Chem Technology Co.,LTD | 400-6206333 13167063860 | anhua.mao@aladdin-e.com | China | 25003 | 65 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Hubei Yangxin Medical Technology Co., Ltd. | 15374522761 | 3003392093@qq.com | China | 8865 | 55 |
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