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ChemicalBook >> CAS DataBase List >>O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7

CAS No.
846549-37-9
Chemical Name:
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
Synonyms
N3-(PEG)7-COOH;azido-peg-acid (n=8);N-(PEG)-COOH (33 atoms);N3-PEG8-NHCOCH2OCH2COOH;Azido-PEG8-NHCOCH2OCH2COOH;N3-PEG8-CH2CH2NHCOCH2OCH2COOH;N3-(PEG)7-COOH (33 ATOMS) 1 G;N-(PEG)-COOH (33 atoms) Novabiochem;2-((Azido-PEG8-carbamoyl)methoxy)acetic acid;-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
CBNumber:
CB8972491
Molecular Formula:
C22H42N4O12
Molecular Weight:
554.59
MDL Number:
MFCD03453234
MOL File:
846549-37-9.mol
MSDS File:
SDS
Last updated:2025-04-18 09:53:02

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Properties

storage temp. Store at +2°C to +8°C.
form Liquid
color Colorless to light yellow
UNSPSC Code 12352106
NACRES NA.22

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P264-P271-P280-P302+P352-P305+P351+P338
Hazard Codes  Xi
Risk Statements  36/37/38
Safety Statements  25
WGK Germany  3
HS Code  2929 90 00

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 price More Price(13)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 8.51021 N?-(PEG)?-COOH (33 atoms) Novabiochem? 846549-37-9 1g $698 2024-03-01 Buy
Sigma-Aldrich 71613 O-(2-Azidoethyl)-O-[2-(diglycolyl-amino)ethyl]heptaethylene glycol ≥90%(oligomerpurity) 846549-37-9 500mg $313.8 2024-03-01 Buy
Biosynth Carbosynth FA29576 O-(2-Azidoethyl)-O-[2-(diglycoly-amino)ethyl]heptaethylene glycol 846549-37-9 500mg $450 2021-12-16 Buy
AK Scientific 2154BB N3-Peg7-cooh 846549-37-9 250mg $488 2021-12-16 Buy
American Custom Chemicals Corporation POL0001643 AZIDO-PEG-ACID 95.00% 846549-37-9 5MG $499.28 2021-12-16 Buy
Product number Packaging Price Buy
8.51021 1g $698 Buy
71613 500mg $313.8 Buy
FA29576 500mg $450 Buy
2154BB 250mg $488 Buy
POL0001643 5MG $499.28 Buy

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Chemical Properties,Uses,Production

Description

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.

Uses

2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

reaction suitability

reaction type: click chemistry
reagent type: cross-linking reagent

IC 50

PEGs

References

[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Preparation Products And Raw materials

Raw materials

Preparation Products

O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Suppliers

Global( 66)Suppliers
Supplier Tel Email Country ProdList Advantage
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32268 58
Wuhan Borenpharm Co., Ltd 		027-65563561 18717150066 3207347307@qq.com CHINA 1238 58
TargetMol Chemicals Inc. 		support@targetmol.com United States 38660 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+86-18621343501; +undefined18621343501 product@acmec-e.com China 33338 58
R&D Scientific Inc. 		+1-2266000236 sales@rdscientific.com Canada 1776 58
Shanxi Tihondan Pharmaceutical Technology Co., Ltd 		+8618235132063 sales@tihondan.com China 3767 58
Jilin Chinese Academy of Sciences-yanshen Technology 		+undefined18143011203 info@chemextension.com China 42056 58
Aladdin Scientific 		tp@aladdinsci.com United States 57505 58
Aladdin Scientific 		tp@aladdinsci.com United States 52924 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580 cooperation@kean-chem.com China 40066 58

View Lastest Price from O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid pictures 2024-10-24 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
846549-37-9
 US $30.00-41.00 / mg 10g TargetMol Chemicals Inc.
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid pictures 2024-02-13 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid
846549-37-9
 US $720.00 / g 1g 98 1 Kg R&D Scientific Inc.
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 azido-peg-acid (n=8) N3-(PEG)7-COOH N-(PEG)-COOH (33 atoms) Novabiochem O-(2-Azidoethyl)-O-[2-(diglycolyl-aMino)ethyl]heptaethylene glycol >=90% (oligoMer purity) O-(2-Azidoethyl)-O-[2-(diglycoly-amino)ethyl]heptaethylene glycol N-(PEG)-COOH (33 atoms) 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid N3-(PEG)7-COOH (33 ATOMS) 1 G 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethylamino]-2-oxoethoxy]acetic acid N3-PEG8-CH2CH2NHCOCH2OCH2COOH -(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 N3-PEG8-CH2CH2NHCOCH2OCH2COOH/Acetic acid,2-[(29-azido-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azanonacos-1-yl)oxy]- 32-Azido-5-oxo-3,9,12,15,18,21,24,27,30-nonaoxa-6-azadotriacontanoic acid Azido-PEG8-NHCOCH2OCH2COOH N3-PEG8-NHCOCH2OCH2COOH 2-{[(26-azido-3,6,9,12,15,18,21,24-octaoxahexacosan-1-yl)carbamoyl]methoxy}acetic acid 846549-37-9 C22H42N4O12 peg