BAY 59-3074
- CAS No.
- 406205-74-1
- Chemical Name:
- BAY 59-3074
- Synonyms
- CS-2278;BAY 59-3074;BAY 59-3074;BAY-59-3074;Bay 59-3074, 10 mM in DMSO;BAY-59-3074; BAY 59-3074; BAY59-3074;inhibit,Cannabinoid Receptor,Bay 59-3074,Inhibitor,Bay 593074,Bay 59 3074;3-[2-Cyano-3-(trifluoromethyl)phenoxy]phenyl4,4,4-trifluoro-1-butanesulfonicacidester;1-Butanesulfonic acid, 4,4,4-trifluoro-, 3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl ester
- CBNumber:
- CB8846466
- Molecular Formula:
- C18H13F6NO4S
- Molecular Weight:
- 453.36
- MDL Number:
- MFCD09027365
- MOL File:
- 406205-74-1.mol
| Boiling point | 490.6±45.0 °C(Predicted) |
|---|---|
| Density | 1.49±0.1 g/cm3(Predicted) |
| storage temp. | Store at +4°C |
| solubility |
DMSO:56.78(Max Conc. mg/mL);135.05(Max Conc. mM) Ethanol:68.17(Max Conc. mg/mL);162.14(Max Conc. mM) |
| form | A crystalline solid |
| color | White to off-white |
| FDA UNII | 5FO5Z101GU |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H320-H335 |
| Precautionary statements | P261-P280-P301+P312-P302+P352-P305+P351+P338 |
BAY 59-3074 price More Price(20)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 21036 | BAY 59-3074 ≥98% | 406205-74-1 | 1mg | $40 | 2024-03-01 | Buy |
| Cayman Chemical | 21036 | BAY 59-3074 ≥98% | 406205-74-1 | 5mg | $130 | 2024-03-01 | Buy |
| Cayman Chemical | 21036 | BAY 59-3074 ≥98% | 406205-74-1 | 10mg | $214 | 2024-03-01 | Buy |
| Cayman Chemical | 21036 | BAY 59-3074 ≥98% | 406205-74-1 | 50mg | $844 | 2024-03-01 | Buy |
| Tocris | 2500 | Bay59-3074 ≥99%(HPLC) | 406205-74-1 | 10 | $167 | 2021-12-16 | Buy |
BAY 59-3074 Chemical Properties,Uses,Production
Uses
Bay 59-3074, is a novel cannabinoid CB1/CB2 receptor partial agonist with antihyperalgesic and antiallodynic effects.
Definition
ChEBI: 4,4,4-trifluoro-1-butanesulfonic acid is an aromatic ether.
Biological Activity
Novel CB 1 /CB 2 receptor partial agonist (K i values are 48.3 and 45.5 nM at human CB 1 and CB 2 receptors respectively). Orally active CB 1 agonist in vivo . Displays anti-hyperalgesic and antiallodynic properties in rat models of chronic neuropathic and inflammatory pain.
in vivo
BAY 59-3074 (0.3-3 mg/kg; oral administration; daily; for 2 weeks; male Wistar rats) treatment improves antihyperalgesic and antiallodynic effects against thermal or mechanical stimuli in rat models of chronic neuropathic and inflammatory pain.
| Animal Model: | Male Wistar rats (160-250 g)[1] |
| Dosage: | 0.3 mg/kg, 1 mg/kg, and 3 mg/kg |
| Administration: | Oral administration; daily; for 2 weeks. |
| Result: | Antiallodynic efficacy in the spared nerve injury model was maintained after 2 weeks of daily administration. Tolerance developed rapidly (within 5 days) for cannabinoid-related side effects. Antihyperalgesic and antiallodynic efficacy was maintained/increased. |
IC 50
CB1: 48.3 nM (Ki); CB2: 45.5 nM (Ki)
BAY 59-3074 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29807 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32277 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38664 | 58 | |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
View Lastest Price from BAY 59-3074 manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-04-30 | Bay 59-3074
406205-74-1
|
US $38.00-119.00 / mg | 97.68% | 10g | TargetMol Chemicals Inc. | ||
![[3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl] 4,4,4-trifluorobutane-1-sulfonate pictures](https://img.chemicalbook.com/ProductImageEN/2020-1/Small/7ba966ea-91bf-485c-9732-b852f25b2798.png) |
2020-01-02 | [3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl] 4,4,4-trifluorobutane-1-sulfonate
406205-74-1
|
US $1.00 / KG | 1KG | Min98% HPLC | g/kg/ton | Career Henan Chemical Co |
-
- Bay 59-3074
406205-74-1
- US $38.00-119.00 / mg
- 97.68%
- TargetMol Chemicals Inc.
-
- [3-[2-cyano-3-(trifluoromethyl)phenoxy]phenyl] 4,4,4-trifluorobutane-1-sulfonate
406205-74-1
- US $1.00 / KG
- Min98% HPLC
- Career Henan Chemical Co