5-(4-PHENOXYBUTOXY)PSORALEN
- CAS No.
- 870653-45-5
- Chemical Name:
- 5-(4-PHENOXYBUTOXY)PSORALEN
- Synonyms
- PAP-1;SPS-4251;7H-Furo[3;PAP-1 ，E0378;4-(4-phenoxybutoxy)-;PAP-1, 10 mM in DMSO;2-g][1]benzopyran-7-one;5-(4-PHENOXYBUTOXY)PSORALEN;5-(4-PHENOXYBUTOXY)PSORALEN;PAP1;PAP-1,5-(4-Phenoxybutoxy)psoralen
- CBNumber:
- CB8370170
- Molecular Formula:
- C21H18O5
- Molecular Weight:
- 350.36
- MDL Number:
- MFCD11114059
- MOL File:
- 870653-45-5.mol
- MSDS File:
- SDS
| Boiling point | 555.8±50.0 °C(Predicted) |
|---|---|
| Density | 1.269 |
| storage temp. | 2-8°C |
| solubility | DMSO: 9 mg/mL |
| form | solid |
| color | white |
| FDA UNII | A62C114Q0Q |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS08 |
|---|---|
| Signal word | Danger |
| Hazard statements | H334 |
| Precautionary statements | P261-P342+P311 |
| Risk Statements | 42/43 |
| Safety Statements | 22-36/37-45 |
| WGK Germany | 3 |
5-(4-PHENOXYBUTOXY)PSORALEN price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | P6124 | 5-(4-Phenoxybutoxy)psoralen ≥98% (HPLC), solid | 870653-45-5 | 5mg | $247 | 2024-03-01 | Buy |
| Sigma-Aldrich | P6124 | 5-(4-Phenoxybutoxy)psoralen ≥98% (HPLC), solid | 870653-45-5 | 25mg | $584.4 | 2024-03-01 | Buy |
| ChemScene | CS-0299 | PAP-1 99.69% | 870653-45-5 | 50mg | $588 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb611724 | PAP-1 | 870653-45-5 | 10mg | $306 | 2021-12-16 | Buy |
| ChemScene | CS-0299 | PAP-1 99.69% | 870653-45-5 | 5mg | $96 | 2021-12-16 | Buy |
5-(4-PHENOXYBUTOXY)PSORALEN Chemical Properties,Uses,Production
Uses
5-(4-Phenoxybutoxy)psoralen (CAS# 870653-45-5) is a selective small molecule blocker of the lymphocyte K+ channel Kv1.3 and is used for the suppression of effector memory T cells in autoimmune diseases.
Biochem/physiol Actions
Selective inhibitor of Kv1.3, voltage-gated K+ channel. PAP-1 (EC50=2 nM) potently inhibits human T effector memory cell proliferation and delayed hypersensitivity. Effective orally or intraperitoneally. 5-(4-Phenoxybutoxy)psoralen has 23-fold selectivity for Kv1.3 over Kv1.5, and 33-125-fold selectivity over other Kv1 family channels.
in vivo
PAP-1 (0.3-3 mg/kg; i.p.; three times daily for 48 hours) prevents delayed type hypersensitivity (DTH) in lewis rats[1].
| Animal Model: | 9- to 11- week-old female Lewis rats[1] |
| Dosage: | Intraperitoneal injection; three times daily for 48 hours |
| Administration: | 0.3, 1, 3 mg/kg |
| Result: | Dose-dependently suppressed the DTH reaction. |
5-(4-PHENOXYBUTOXY)PSORALEN Preparation Products And Raw materials
Raw materials
Preparation Products
5-(4-PHENOXYBUTOXY)PSORALEN Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29806 | 58 |
| Finetech Industry Limited | +86-27-8746-5837 +8619945049750 | info@finetechnology-ind.com | China | 9643 | 58 |
| Hefei Hirisun Pharmatech Co., Ltd | +8615056975894 | shawn@hirisunpharm.com | CHINA | 9911 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3135 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38671 | 58 | |
| Hu Bei Jiutian Bio-medical Technology CO.,Ltd | 027-88013699 17354350817 | Ryan@jiutian-bio.com | China | 5997 | 58 |
